AMIGO2 - adhesion molecule with Ig like domain 2 Gene

Also Known as ALI1; DEGA; AMIGO-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 347902

About AMIGO2

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,075,707-47,079,959 (from NCBI)

This gene has 3 transcripts (splice variants), 168 orthologues and 2 paralogues. Broad expression in gall bladder (RPKM 9.4), urinary bladder (RPKM 8.8) and 23 other tissues.

Summary

Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of programmed cell death. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be integral component of membrane. Biomarker of gastric adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022]

AMIGO2 Products (3)

mRNA Protein Name
NM_001143668.1 NP_001137140.1 amphoterin-induced protein 2 precursor
NM_001370299.1 NP_001357228.1 amphoterin-induced protein 2 precursor
NM_181847.4 NP_862830.1 amphoterin-induced protein 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21078624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMIGO2 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (94 - 153)

LRR_1

LRR_1: Leucine Rich Repeat (166 - 183)

Ig_2

Ig_2: Immunoglobulin domain (300 - 378)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

amphoterin-induced protein 2

  • alivin 1

AMIGO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AMIGO2 Q86SJ2 CACNA1A Homo sapiens O00555
Y2H
21078624
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AMIGO2 Proteins

Cat. No. Product Name Accession Purity
HY-P7495 AMIGO2 Protein, Human (HEK293, His) Q86SJ2 (V40-A392) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P7496 AMIGO2 Protein, Human (HEK293, Fc) Q86SJ2 (G39-H393) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Parkinson Disease 8, Autosomal Dominant

  • Parkinson Disease 8

  • Autosomal Dominant Parkinson Disease 8

  • PARK8

  • Parkinson'S Disease 8

  • Autosomal Dominant Parkinson'S Disease 8

  • Parkinson Disease-8

  • Parkinson Disease, Type 8, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00658 AMIGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18195 Amigo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24669 Amigo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AMIGO2 VGNC VGNC:69680
Rattus norvegicus AMIGO2 RGD RGD:727911
Mus musculus AMIGO2 MGD MGI:2145995
Bos taurus AMIGO2 VGNC VGNC:25866
Felis catus AMIGO2 VGNC VGNC:59766
Canis familiaris AMIGO2 VGNC VGNC:37832
Others AMIGO2 NCBI