ITIH3 - inter-alpha-trypsin inhibitor heavy chain 3 Gene

Also Known as H3P; SHAP; ITI-HC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3699

About ITIH3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,794,796-52,808,797 (from NCBI)

This gene has 11 transcripts (splice variants), 299 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 228.8).

Summary

This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]

ITIH3 Products (10)

mRNA Protein Name
NM_001392019.1 NP_001378948.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 precursor
NM_001392020.1 NP_001378949.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 2 precursor
NM_001392021.1 NP_001378950.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 3 precursor
NM_001392022.1 NP_001378951.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 5 precursor
NM_001392023.1 NP_001378952.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 6 precursor
NM_001392024.1 NP_001378953.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 7 precursor
NM_001392025.1 NP_001378954.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 8 precursor
NM_001392026.1 NP_001378955.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 9 precursor
NM_001392027.1 NP_001378956.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 10 precursor
NM_002217.4 NP_002208.3 inter-alpha-trypsin inhibitor heavy chain H3 isoform 4 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16873769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITIH3 Protein Structure

VIT

VIT: Vault protein inter-alpha-trypsin domain (41 - 158)

VWA

VWA: von Willebrand factor type A domain (284 - 456)

ITI_HC_C

ITI_HC_C: Inter-alpha-trypsin inhibitor heavy chain C-terminus (685 - 871)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H3

  • ITI heavy chain H3

Recombinant ITIH3 Proteins

Cat. No. Product Name Accession Purity
HY-P70407 ITIH3 Protein, Human (HEK293, His) Q06033-1 (L35-D651) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Immunoglobulin Heavy-And-Light Chain

  • Ah/Al Amyloidosis

  • Ig Heavy-And-Light-Chain Amyloidosis
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06976 ITIH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19699 Itih3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26194 Itih3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITIH3 MGD MGI:96620
Macaca mulatta ITIH3 VGNC VGNC:73795
Felis catus ITIH3 VGNC VGNC:67861
Rattus norvegicus ITIH3 RGD RGD:620633
Bos taurus ITIH3 VGNC VGNC:30335
Canis familiaris ITIH3 VGNC VGNC:103686
Others ITIH3 NCBI