Grem1 - gremlin 1, DAN family BMP antagonist Gene

Also Known as drm; Cktsf1b1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50566

Summary

Predicted to enable several functions, including BMP binding activity; protein homodimerization activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of cell growth; negative regulation of monocyte chemotaxis; and positive regulation of angiogenesis. Acts upstream of or within negative regulation of osteoblast differentiation. Located in cell surface and extracellular space. Orthologous to human GREM1 (gremlin 1, Dan family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Grem1 Products (1)

mRNA Protein Name
NM_019282.3 NP_062155.1 gremlin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10722723 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
9234736 RGD
involved in negative regulation of leukocyte chemotaxis IDA
IDA: Inferred from direct assay
15528323 RGD
involved in negative regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
15528323 RGD
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
27910957 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17077323 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10722723 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
10722723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gremlin-1

  • cysteine knot superfamily 1, BMP antagonist 1

  • down-regulated in Mos-transformed cells protein

  • gremlin 1 homolog, cysteine knot superfamily

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112056 DIM-C-pPhCO2Me 99.29% Unkown
HY-RS05784 GREM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17341 Grem1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23796 Grem1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990426 Anti-GREM1/Gremlin Antibody 98.59% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grem1 NCBI NCBI:26585