Rgs12 - regulator of G-protein signaling 12 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54292

Summary

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in termination of G protein-coupled receptor signaling pathway. Located in several cellular components, including apical dendrite; cytosol; and neuronal cell body. Part of protein-containing complex. Colocalizes with synapse. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Apr 2022]

Rgs12 Products (1)

mRNA Protein Name
NM_019339.2 NP_062212.2 regulator of G-protein signaling 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
11387333 RGD
enables GTPase activator activity IDA
IDA: Inferred from direct assay
9651375 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11387333 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G protein-coupled receptor signaling pathway IEP
IEP: Inferred from expression pattern
9651375 RGD
involved in termination of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11130074 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
16819986 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
16819986 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16819986 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16819986 RGD
located in nucleus IDA
IDA: Inferred from direct assay
16819986 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17380122 RGD
located in synapse IDA
IDA: Inferred from direct assay
16819986 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of G-protein signaling 12

  • regulator of G-protein signalling 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11905 RGS12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20481 Rgs12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26989 Rgs12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs12 NCBI NCBI:6002