RGS12 - regulator of G protein signaling 12 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6002

About RGS12

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,285,891-3,439,913 (from NCBI)

This gene has 26 transcripts (splice variants), 142 orthologues and 23 paralogues. Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues.

Summary

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

RGS12 Products (12)

mRNA Protein Name
NM_001394154.1 NP_001381083.1 regulator of G-protein signaling 12 isoform 1
NM_001394155.1 NP_001381084.1 regulator of G-protein signaling 12 isoform 1
NM_001394156.1 NP_001381085.1 regulator of G-protein signaling 12 isoform 2
NM_001394157.1 NP_001381086.1 regulator of G-protein signaling 12 isoform 4
NM_001394158.1 NP_001381087.1 regulator of G-protein signaling 12 isoform 5
NM_001394159.1 NP_001381088.1 regulator of G-protein signaling 12 isoform 6
NM_001394161.1 NP_001381090.1 regulator of G-protein signaling 12 isoform 7
NM_001394162.1 NP_001381091.1 regulator of G-protein signaling 12 isoform 7
NM_001394163.1 NP_001381092.1 regulator of G-protein signaling 12 isoform 7
NM_002926.5 NP_002917.1 regulator of G-protein signaling 12 isoform 2
NM_198227.2 NP_937870.1 regulator of G-protein signaling 12 isoform 3
NM_198229.3 NP_937872.1 regulator of G-protein signaling 12 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GTPase regulator activity IDA
IDA: Inferred from direct assay
9651375 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS12 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (24 - 95)

RGS

RGS: Regulator of G protein signaling domain (715 - 831)

RBD

RBD: Raf-like Ras-binding domain (962 - 1032)

RBD

RBD: Raf-like Ras-binding domain (1035 - 1104)

GoLoco

GoLoco: GoLoco motif (1188 - 1209)

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  • 1376 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 12

  • regulator of G-protein signalling 12

RGS12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RGS12 O14924 PM20D2 Homo sapiens Q8IYS1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RGS12 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89821 RGS12 Antibody (YA9165) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Mosaic Variegated Aneuploidy Syndrome

  • Warburton-Anyane-Yeboa Syndrome

  • Mva Syndrome

  • Mosaic Variegated Aneuplody Microcephaly Syndrome

  • Warburton Anyane Yeboa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11905 RGS12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20481 Rgs12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26989 Rgs12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RGS12 VGNC VGNC:100266
Mus musculus RGS12 MGD MGI:1918979
Canis familiaris RGS12 VGNC VGNC:45522
Felis catus RGS12 VGNC VGNC:69312
Rattus norvegicus RGS12 RGD RGD:3564
Others RGS12 NCBI