KLK7 - kallikrein related peptidase 7 Gene

Also Known as hK7; SCCE; PRSS6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5650

About KLK7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,976,468-50,984,064 (from NCBI)

This gene has 6 transcripts (splice variants), 107 orthologues and 12 paralogues. Biased expression in skin (RPKM 68.1) and esophagus (RPKM 25.3).

Summary

This gene encodes a member of the Kallikrein subfamily of serine proteases. These Enzymes have diverse physiological functions and many Kallikrein genes are biomarkers for Cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in Cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of Cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen Kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

KLK7 Products (4)

mRNA	Protein	Name
NM_001207053.2	NP_001193982.1	kallikrein-7 isoform 2
NM_001243126.1	NP_001230055.1	kallikrein-7 isoform 3
NM_005046.4	NP_005037.1	kallikrein-7 isoform 1 preproprotein
NM_139277.2	NP_644806.1	kallikrein-7 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	17012259	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of antibacterial peptide production	IMP IMP: Inferred from mutant phenotype	17012259	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in epidermal lamellar body	IDA IDA: Inferred from direct assay	15675955	GOA
located in extracellular space	IMP IMP: Inferred from mutant phenotype	17012259	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK7 Protein Structure

Trypsin

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
kallikrein-7	kallikrein 7 (chymotryptic, stratum corneum)

Recombinant KLK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70163	Kallikrein-7 Protein, Human (HEK293, His, solution)	P49862 (E23-H252)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76466	Kallikrein-7 Protein, Human (HEK293, His)	NP_005037.1 (E23-R253)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Netherton Syndrome	NETH Ns Netherton Disease Comel-Netherton Syndrome Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige Bamboo Hair Syndrome Ichthyosis Linearis Circumflexa Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige Ilc Nts N Syndrome
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Occupational Dermatitis	Dermatitis, Occupational Occupational Allergic Contact Dermatitis Occupational Eczema
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Psoriasis
Peeling Skin Syndrome	Deciduous Skin Familial Continuous Skin Peeling Syndrome Idiopathic Deciduous Skin Keratosis Exfoliativa Congenita Pss Peeling Skin Disease Skin Peeling Syndrome Familial Continuous Skin Peeling Keratolysis Exfoliativa Congenita Exfoliation Syndrome Keratolysis Exfoliativa
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 4b	Harlequin Ichthyosis Autosomal Recessive Congenital Ichthyosis 4b Hi Harlequin Fetus ARCI4B Ichthyosis Congenita, Harlequin Fetus Type Harlequin Type Ichthyosis 'Harlequin Fetus' Harlequin Type Ichthyosis Congenita Harlequin Type Ichthyosis Fetalis Harlequin Baby Syndrome Ichthyosis Congenita, Harlequin Type Ichthyosis Fetalis, Harlequin Type Ichthyosis Congenita Harlequin Fetus Type Ichthyosis, Harlequin Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4669	LM-030	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124714	DKFZ-251	Inhibitor	95.93%	Unkown
HY-150085	GSK951	Inhibitor	/	Unkown
HY-P11840	KLK5-IN-1	Inhibitor	/	Unkown
HY-RS07384	KLK6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07385	KLK7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-186007	KLK7 modulator-1		/	Unkown
HY-RS17165	Klk7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23615	Klk7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24511	Klk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992250	Anti-KLK7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLK7	RGD	RGD:1306420
Felis catus	KLK7	VGNC	VGNC:67967
Mus musculus	KLK7	MGD	MGI:1346336
Macaca mulatta	KLK7	VGNC	VGNC:74193
Bos taurus	KLK7	VGNC	VGNC:30681
Others	KLK7	NCBI