KLK5-IN-1
KLK5-IN-1 is a selective kallikrein 5 (KLK5) inhibitor with an IC50 of 14 nM and a Ki of 11 nM. KLK5-IN-1 reduces KLK5-mediated PAR2-dependent calcium mobilization. KLK5-IN-1 improves epithelial barrier integrity. KLK5-IN-1 can be used in research related to atopic dermatitis and Netherton syndrome.
For research use only. We do not sell to patients.
- Formula: C69H96N20O21S2
- Molecular Weight:1605.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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KLK5 14 nM (IC50) |
PAR2 |
KLK5-IN-1 (Compound 7) potently and selectively inhibits purified KLK5 with an IC50 of 14 nM and a Ki of 11 nM, with no activity against KLK7, KLK8, or KLK14 at concentrations above 1 μM[1].
KLK5-IN-1 (2.5-40 μM; 1 h) dose-dependently inhibits rKLK5-mediated PAR2 activation in N/TERT keratinocytes, with complete inhibition observed at 10 μM[1].
KLK5-IN-1 (100 nM-10 μM) dose-dependently inhibits elevated endogenous KLK5 activity in NS keratinocytes but has no significant effect on KLK5 activity in healthy donor keratinocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1605.75
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Formula C69H96N20O21S2
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Sequence
cyclo(Gly-Phe-Cys-Thr-Arg-Ser-Asn-Pro-Pro-Glu-Cys-Trp-Pro-Asn) (Disulfide bridge: Cys3-Cys11)
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Sequence Shortening
cyclo(GFCTRSNPPECWPN) (Disulfide bridge: Cys3-Cys11)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)