2. Immunology/Inflammation GPCR/G Protein
  3. Kallikrein Protease Activated Receptor (PAR)
  4. KLK5-IN-1

KLK5-IN-1 is a selective kallikrein 5 (KLK5) inhibitor with an IC50 of 14 nM and a Ki of 11 nM. KLK5-IN-1 reduces KLK5-mediated PAR2-dependent calcium mobilization. KLK5-IN-1 improves epithelial barrier integrity. KLK5-IN-1 can be used in research related to atopic dermatitis and Netherton syndrome.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

KLK5-IN-1

KLK5-IN-1 Chemical Structure

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KLK5-IN-1 Related Antibodies

Top Publications Citing Use of Products

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KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

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PAR1 PAR2 PAR4

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Description

KLK5-IN-1 is a selective kallikrein 5 (KLK5) inhibitor with an IC50 of 14 nM and a Ki of 11 nM. KLK5-IN-1 reduces KLK5-mediated PAR2-dependent calcium mobilization. KLK5-IN-1 improves epithelial barrier integrity. KLK5-IN-1 can be used in research related to atopic dermatitis and Netherton syndrome[1].

IC50 & Target[1]

KLK5

14 nM (IC50)

PAR2

 

In Vitro

KLK5-IN-1 (Compound 7) potently and selectively inhibits purified KLK5 with an IC50 of 14 nM and a Ki of 11 nM, with no activity against KLK7, KLK8, or KLK14 at concentrations above 1 μM[1].
KLK5-IN-1 (2.5-40 μM; 1 h) dose-dependently inhibits rKLK5-mediated PAR2 activation in N/TERT keratinocytes, with complete inhibition observed at 10 μM[1].
KLK5-IN-1 (100 nM-10 μM) dose-dependently inhibits elevated endogenous KLK5 activity in NS keratinocytes but has no significant effect on KLK5 activity in healthy donor keratinocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KLK5-IN-1 Related Antibodies
Molecular Weight

1605.75

Formula

C69H96N20O21S2
Sequence

cyclo(Gly-Phe-Cys-Thr-Arg-Ser-Asn-Pro-Pro-Glu-Cys-Trp-Pro-Asn) (Disulfide bridge: Cys3-Cys11)
Sequence Shortening

cyclo(GFCTRSNPPECWPN) (Disulfide bridge: Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KLK5-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLK5-IN-1KallikreinProtease Activated Receptor (PAR)KLKKallikrein-related peptidaseThrombin receptorsKLK8Netherton syndromePAR2kallikrein 5N/TERT keratinocytesimmortalized keratinocytesKLK5KLK14atopic dermatitisKLK7Inhibitorinhibitorinhibit

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HY-P11840
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