KLK5-IN-1
KLK5-IN-1 is a selective kallikrein 5 (KLK5) inhibitor with an IC50 of 14 nM and a Ki of 11 nM. KLK5-IN-1 reduces KLK5-mediated PAR2-dependent calcium mobilization. KLK5-IN-1 improves epithelial barrier integrity. KLK5-IN-1 can be used in research related to atopic dermatitis and Netherton syndrome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C69H96N20O21S2
- 分子量:1605.75
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
KLK5 14 nM (IC50) |
PAR2 |
体外実験
KLK5-IN-1 (Compound 7) potently and selectively inhibits purified KLK5 with an IC50 of 14 nM and a Ki of 11 nM, with no activity against KLK7, KLK8, or KLK14 at concentrations above 1 μM[1].
KLK5-IN-1 (2.5-40 μM; 1 h) dose-dependently inhibits rKLK5-mediated PAR2 activation in N/TERT keratinocytes, with complete inhibition observed at 10 μM[1].
KLK5-IN-1 (100 nM-10 μM) dose-dependently inhibits elevated endogenous KLK5 activity in NS keratinocytes but has no significant effect on KLK5 activity in healthy donor keratinocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1605.75
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分子式 C69H96N20O21S2
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配列
cyclo(Gly-Phe-Cys-Thr-Arg-Ser-Asn-Pro-Pro-Glu-Cys-Trp-Pro-Asn) (Disulfide bridge: Cys3-Cys11)
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シーケンスの短縮
cyclo(GFCTRSNPPECWPN) (Disulfide bridge: Cys3-Cys11)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KLK5-IN-1 関連分類
HY-P11840 関連分類
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