Ccr1 - C-C motif chemokine receptor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 57301

About Ccr1

Biased expression in Lung (RPKM 74.6), Spleen (RPKM 54.4) and 9 other tissues.

Summary

Enables C-C chemokine binding activity. Involved in cerebellum development and inflammatory response. Located in external side of plasma membrane and neuronal cell body. Used to study colitis. Biomarker of anterior uveitis. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ccr1 Products (1)

mRNA Protein Name
NM_020542.2 NP_065417.1 C-C chemokine receptor type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine binding IDA
IDA: Inferred from direct assay
11091494 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23110133 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
12541321 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
15764707 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr1 Protein Structure

7tmA_CCR1

7tmA_CCR1: cd15183 (34 - 311)

7tmA_CCR1

7tmA_CCR1: cd15183 (34 - 61)

7tmA_CCR1

7tmA_CCR1: cd15183 (68 - 93)

7tmA_CCR1

7tmA_CCR1: cd15183 (105 - 135)

7tmA_CCR1

7tmA_CCR1: cd15183 (147 - 169)

7tmA_CCR1

7tmA_CCR1: cd15183 (195 - 224)

7tmA_CCR1

7tmA_CCR1: cd15183 (231 - 261)

7tmA_CCR1

7tmA_CCR1: cd15183 (279 - 304)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 1

  • chemokine (C-C motif) receptor 1

  • macrophage inflammatory protein-1 alpha receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15545 AZD-4818 99.10% Phase 2
HY-U00350 CCX354 Antagonist 99.18% Phase 2
HY-120588 BI 639667 Antagonist 98.87% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12080 BX471 Antagonist 99.98% Unkown
HY-18611A Abaucin Antagonist 99.59% Unkown
HY-12080A BX471 hydrochloride Antagonist 99.94% Unkown
HY-18611 Abaucin hydrochloride Antagonist 99.94% Unkown
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-103355 YM022 Antagonist 99.87% Unkown
HY-P4191A Met-RANTES (human) acetate Antagonist 99.39% Unkown
HY-15546 BMS-817399 Antagonist 99.66% Unkown
HY-124759 CCR1 antagonist 9 Antagonist 99.65% Unkown
HY-P4191 Met-RANTES (human) Antagonist / Unkown
HY-12079 CP-481715 Antagonist / Unkown
HY-124668 CCR1 antagonist 12 Antagonist / Unkown
HY-124668A CCR1 antagonist 13 Antagonist / Unkown
HY-15544 CCR1 antagonist 10 Antagonist / Unkown
HY-185661 IBS007125 Inhibitor / Unkown
HY-171476 CP-865569 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr1 NCBI NCBI:1230