XPO5 - exportin 5 Gene
Also Known as exp5
Species: Homo sapiens
About XPO5
This gene has 12 transcripts (splice variants), 224 orthologues and 1 paralogue. Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues.
Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
XPO5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_020750.3 | NP_065801.1 | exportin-5 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RISC complex binding |
IDA
IDA: Inferred from direct assay
|
19965479 | GOA |
| enables mRNA binding |
IDA
IDA: Inferred from direct assay
|
21297638 | GOA |
| enables nuclear export signal receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
14681208 | GOA |
| contributes to pre-miRNA binding |
IDA
IDA: Inferred from direct assay
|
14681208 | GOA |
| enables pre-miRNA binding |
IDA
IDA: Inferred from direct assay
|
21297638 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11777942 | GOA |
| enables small GTPase binding |
IDA
IDA: Inferred from direct assay
|
11777942 | GOA |
| enables small GTPase binding |
IPI
IPI: Inferred from physical interaction
|
14681208 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in pre-miRNA export from nucleus |
IDA
IDA: Inferred from direct assay
|
15613540 | GOA |
| involved in pre-miRNA export from nucleus |
IMP
IMP: Inferred from mutant phenotype
|
14681208 | GOA |
| involved in protein export from nucleus |
IDA
IDA: Inferred from direct assay
|
11777942 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of RISC complex |
IDA
IDA: Inferred from direct assay
|
19965479 | GOA |
| part of RNA nuclear export complex |
IDA
IDA: Inferred from direct assay
|
14681208 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11777942 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11777942 | GOA |
XPO5 Protein Structure
Xpo1: Exportin 1-like protein (110 - 271)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1204 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
exportin-5 |
|
XPO5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82355 | Exportin 5 Antibody (YA2100) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pleuropulmonary Blastoma |
|
|
| Chromosomal Deletion Syndrome |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS15891 | XPO5 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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