Ncstn - nicastrin Gene

Also Known as Nct; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; 9430068N19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59287

Summary

Contributes to aspartic endopeptidase activity, intramembrane cleaving. Acts upstream of or within several processes, including amyloid precursor protein metabolic process; positive regulation of amyloid precursor protein biosynthetic process; and regulation of synaptic plasticity. Located in several cellular components, including Golgi apparatus; lysosome; and synaptic vesicle. Part of gamma-secretase complex. Is expressed in several structures, including brain and genitourinary system. Used to study chronic myeloid leukemia; schizophrenia; and urinary bladder Cancer. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Apr 2022]

Ncstn Products (1)

mRNA Protein Name
NM_021607.3 NP_067620.3 nicastrin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to aspartic endopeptidase activity, intramembrane cleaving IGI
IGI: Inferred from genetic interaction
16371134 MGI
contributes to endopeptidase activity IDA
IDA: Inferred from direct assay
19457123 MGI
contributes to endopeptidase activity IMP
IMP: Inferred from mutant phenotype
17913918 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15474363 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27008863 MGI
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
17913918 MGI
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
27008863 MGI
acts upstream of or within amyloid precursor protein biosynthetic process IMP
IMP: Inferred from mutant phenotype
18201567 MGI
acts upstream of or within amyloid precursor protein metabolic process IMP
IMP: Inferred from mutant phenotype
21597003 MGI
acts upstream of or within amyloid-beta formation IGI
IGI: Inferred from genetic interaction
16371134 MGI
acts upstream of or within amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
17913918 MGI
acts upstream of or within cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
24889619 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
27008863 MGI
acts upstream of or within epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
17913918 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17913918 MGI
acts upstream of or within glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24889619 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
19494151 MGI
acts upstream of or within myeloid cell homeostasis IMP
IMP: Inferred from mutant phenotype
17913918 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19494151 MGI
acts upstream of or within positive regulation of amyloid precursor protein biosynthetic process IMP
IMP: Inferred from mutant phenotype
23826707 MGI
acts upstream of or within regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
24889619 MGI
acts upstream of or within short-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
24889619 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12646573 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12646573 MGI
part of gamma-secretase complex IDA
IDA: Inferred from direct assay
16371134 MGI
located in lysosome IDA
IDA: Inferred from direct assay
25592972 MGI
located in membrane IDA
IDA: Inferred from direct assay
11943765 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12646573 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
21597003 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
25438880 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nicastrin

Recombinant Ncstn Proteins

Cat. No. Product Name Accession Purity
HY-P74696 Nicastrin Protein, Mouse (HEK293, His) P57716 (G28-E668) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74697 Nicastrin Protein, Mouse (HEK293, hFc) P57716 (G28-E668) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09103 NCSTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18670 Ncstn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25156 Ncstn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncstn NCBI NCBI:23385