Pfn1 - profilin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64303

Summary

Enables phosphatidylinositol-4,5-bisphosphate binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of nucleobase-containing compound metabolic process; positive regulation of stress fiber assembly; and positive regulation of viral transcription. Located in cytoplasm; neuron projection; and synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Used to study membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfn1 Products (1)

mRNA Protein Name
NM_022511.2 NP_071956.2 profilin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
16741017 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12967995 RGD
enables signaling receptor binding IDA
IDA: Inferred from direct assay
10966486 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
10703666 RGD
involved in positive regulation of DNA metabolic process IDA
IDA: Inferred from direct assay
10966486 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
12740026 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10966486 RGD
involved in positive regulation of viral transcription IMP
IMP: Inferred from mutant phenotype
12740026 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
8297366 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
15654839 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
15654839 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15654839 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
15654839 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

profilin-1

  • profilin I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136808 Pfn1-IN-1 Inhibitor 99.17% Unkown
HY-116903 Pfn1-IN-2 99.86% Unkown
HY-RS10368 PFN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22276 Pfn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28799 Pfn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfn1 NCBI NCBI:5216