Wwp2 - WW domain containing E3 ubiquitin protein ligase 2 Gene

Also Known as AIP2; 1300010O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66894

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein Ligase activity. Involved in cellular protein metabolic process and regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Wwp2 Products (1)

mRNA Protein Name
NM_025830.4 NP_080106.1 NEDD4-like E3 ubiquitin-protein ligase WWP2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IGI
IGI: Inferred from genetic interaction
21427722 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15047715 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21427722 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15047715 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19997087 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15047715 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15047715 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15047715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21427722 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19997087 MGI
involved in protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
19997087 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
15047715 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21427722 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15047715 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15047715 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD4-like E3 ubiquitin-protein ligase WWP2

  • HECT-type E3 ubiquitin transferase WWP2

  • WW domain-containing protein 2

  • WW domain-containing protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134417 NSC2805 Inhibitor 99.42% Unkown
HY-168601 WWP1/2-IN-1 Inhibitor / Unkown
HY-180107 H36-E4 Inhibitor 98.57% Unkown
HY-180108 H111-H7 Inhibitor 98.14% Unkown
HY-RS15861 WWP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18265 Wwp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24744 Wwp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wwp2 NCBI NCBI:11060