WWP2 - WW domain containing E3 ubiquitin protein ligase 2 Gene

Also Known as AIP2; WWp2-like

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11060

About WWP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,762,332-69,941,739 (from NCBI)

This gene has 20 transcripts (splice variants), 132 orthologues and 24 paralogues. Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a member of the Nedd4 family of E3 Ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

WWP2 Products (5)

mRNA	Protein	Name
NM_001270453.2	NP_001257382.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 4
NM_001270454.2	NP_001257383.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL
NM_001270455.2	NP_001257384.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-N
NM_007014.5	NP_008945.2	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL
NM_199424.3	NP_955456.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19274063	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9647693	GOA
enables transcription factor binding	IPI IPI: Inferred from physical interaction	19651900	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19274063	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	18776082	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in extracellular transport	IMP IMP: Inferred from mutant phenotype	22315426	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18776082	GOA
involved in negative regulation of protein transport	IMP IMP: Inferred from mutant phenotype	18776082	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19274063	GOA
involved in negative regulation of transporter activity	IDA IDA: Inferred from direct assay	18776082	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19274063	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24105792	GOA
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	18776082	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22315426	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	17289006	GOA
involved in regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	17289006	GOA
involved in regulation of potassium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17289006	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19274063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWP2 Protein Structure

HECT

0
200
400
600
800
870 a.a.

Protein Preferred Names	Protein Names
NEDD4-like E3 ubiquitin-protein ligase WWP2	HECT-type E3 ubiquitin transferase WWP2

WWP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WWP2	O00308	HNRNPUL1	Homo sapiens	Q9BUJ2	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	HNRNPUL1	Homo sapiens	Q9BUJ2	Validated Y2H	32296183
Intra	WWP2	O00308	LGALS9B	Homo sapiens	Q3B8N2	Y2H Array	25416956
Intra	WWP2	O00308	LGALS9B	Homo sapiens	Q3B8N2	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	SNRPC	Homo sapiens	Q5TAL4	Validated Y2H	25416956
Intra	WWP2	O00308	GGN	Homo sapiens	Q86UU5	Validated Y2H	32296183
Intra	WWP2	O00308	SMAD2	Homo sapiens	Q15796	Anti Bait CoIP	21258410
Intra	WWP2	O00308	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	WWP2	O00308	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	WWP2	O00308	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	WWP2	O00308	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	WWP2	O00308	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	WWP2	O00308	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	WWP2	O00308	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	WWP2	O00308	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	WWP2	O00308	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	WWP2	O00308	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	WWP2	O00308	NHERF2	Homo sapiens	Q15599	Validated Y2H	32296183
Intra	WWP2	O00308	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	WWP2	O00308	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	WWP2	O00308	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	WWP2	O00308	EFCAB3	Homo sapiens	Q8N7B9-2	Validated Y2H	32296183
Intra	WWP2	O00308	SMR3A	Homo sapiens	Q99954	Validated Y2H	32296183
Intra	WWP2	O00308	ANKRD44	Homo sapiens	Q8N8A2	Y2H Array	31515488
Intra	WWP2	O00308	ANKRD44	Homo sapiens	Q8N8A2	Validated Y2H	25416956
Intra	WWP2	O00308	PRKAA2	Homo sapiens	P54646	Validated Y2H	32296183
Intra	WWP2	O00308	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	WWP2	O00308	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	WWP2	O00308	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	WWP2	O00308	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	32296183
Intra	WWP2	O00308	ARRDC1	Homo sapiens	Q8N5I2	Y2H	23236378
Intra	WWP2	O00308	ARRDC1	Homo sapiens	Q8N5I2	Validated Y2H	32296183
Intra	WWP2	O00308	ARRDC1	Homo sapiens	Q8N5I2	Anti Tag CoIP	33961781
Intra	WWP2	O00308	ARRDC1	Homo sapiens	Q8N5I2	Anti Tag CoIP	28514442
Intra	WWP2	O00308	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	WWP2	O00308	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	WWP2	O00308	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	WWP2	O00308	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	WWP2	O00308	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	WWP2	O00308	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	WWP2	O00308	TPP1	Homo sapiens	O14773	Validated Y2H	32814053
Intra	WWP2	O00308	TPP1	Homo sapiens	O14773	Y2H Array	32814053
Intra	WWP2	O00308	TPP1	Homo sapiens	O14773	Y2H Pooling	32814053
Intra	WWP2	O00308	ARRDC3	Homo sapiens	Q96B67	Y2H	23236378
Intra	WWP2	O00308	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
Intra	WWP2	O00308	ADARB1	Homo sapiens	P78563	Anti Tag CoIP	21847096
Intra	WWP2	O00308	WIPF1	Homo sapiens	O43516	Validated Y2H	25416956
Intra	WWP2	O00308	WIPF1	Homo sapiens	O43516	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	WIPF1	Homo sapiens	O43516	Y2H	21516116
Intra	WWP2	O00308	SMAD3	Homo sapiens	P84022	Anti Tag CoIP	21258410
Intra	WWP2	O00308	UBE2E3	Homo sapiens	Q969T4	Validated Y2H	32296183
Intra	WWP2	O00308	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	WWP2	O00308	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	25416956
Intra	WWP2	O00308	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	WWP2	O00308	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	WWP2	O00308	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	WWP2	O00308	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	WWP2	O00308	CPSF6	Homo sapiens	Q16630	Anti Tag CoIP	33961781
Intra	WWP2	O00308	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	WWP2	O00308	SMARCD1	Homo sapiens	Q96GM5	Anti Tag CoIP	33961781
Intra	WWP2	O00308	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	WWP2	O00308	TRAF4	Homo sapiens	Q9BUZ4	Y2H	21516116
Intra	WWP2	O00308	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	WWP2	O00308	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	WWP2	O00308	SNRPB	Homo sapiens	P14678-2	Validated Y2H	32296183
Intra	WWP2	O00308	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	WWP2	O00308	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	WWP2	O00308	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	WWP2	O00308	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	WWP2	O00308	SMAD7	Homo sapiens	O15105	Pull Down	21258410
Intra	WWP2	O00308	MED25	Homo sapiens	Q71SY5	Validated Y2H	32296183
Intra	WWP2	O00308	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	WWP2	O00308	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	WWP2	O00308	RNF11	Homo sapiens	Q9Y3C5	Y2H	15231748
Intra	WWP2	O00308	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	WWP2	O00308	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	WWP2	O00308	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	WWP2	O00308	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	WWP2	O00308	POU5F1	Homo sapiens	Q01860	Pull Down	19274063
Intra	WWP2	O00308	POU5F1	Homo sapiens	Q01860	Ubiquitinase Assay	19274063
Intra	WWP2	O00308	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	WWP2	O00308	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	WWP2	O00308	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	WWP2	O00308	WDR5	Homo sapiens	P61964	Validated Y2H	32296183
Intra	WWP2	O00308	CLN6	Homo sapiens	Q9NWW5	Y2H Pooling	32814053
Intra	WWP2	O00308	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32814053
Intra	WWP2	O00308	CLN6	Homo sapiens	Q9NWW5	Y2H Array	32814053
Intra	WWP2	O00308	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	25416956
Intra	WWP2	O00308	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	25416956
Intra	WWP2	O00308	UBA1	Homo sapiens	P22314	Y2H Pooling	32814053
Intra	WWP2	O00308	UBA1	Homo sapiens	P22314	Validated Y2H	32814053
Intra	WWP2	O00308	UBA1	Homo sapiens	P22314	Y2H Array	32814053
Intra	WWP2	O00308	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	WWP2	O00308	HEXB	Homo sapiens	P07686	Y2H Array	32814053
Intra	WWP2	O00308	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	WWP2	O00308	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	WWP2	O00308	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	WWP2	O00308	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	WWP2	O00308	LITAF	Homo sapiens	Q99732	Y2H Pooling	32814053
Intra	WWP2	O00308	LITAF	Homo sapiens	Q99732	Validated Y2H	32814053
Intra	WWP2	O00308	LITAF	Homo sapiens	Q99732	Y2H Array	32814053
Intra	WWP2	O00308	RASD1	Homo sapiens	Q9Y272	Validated Y2H	32296183
Intra	WWP2	O00308	FBXL18	Homo sapiens	Q96D16	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	WWP2	O00308	UBTD1	Homo sapiens	Q9HAC8	Validated Y2H	32296183
Intra	WWP2	O00308	IFIT2	Homo sapiens	Q8IZ03	Validated Y2H	32296183
Intra	WWP2	O00308	q8wu02_human	Homo sapiens	Q8WU02	Y2H Prey Pooling	25416956
Intra	WWP2	O00308	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	WWP2	O00308	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	WWP2	O00308	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	WWP2	O00308	SNRPC	Homo sapiens	P09234	Validated Y2H	32296183
Intra	WWP2	O00308	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
Intra	WWP2	O00308	ENTREP1	Homo sapiens	Q15884	Y2H	34927784
Intra	WWP2	O00308	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	WWP2	O00308	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	WWP2	O00308	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	WWP2	O00308	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	WWP2	O00308	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	WWP2	O00308	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WWP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77507	WWP2 Protein, Human (sf9, His-GST)	O00308-1 (M1-E870)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spondyloepiphyseal Dysplasia, Nishimura Type	SEDN Spondyloepiphyseal Dysplasia Nishimura Type
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134417	NSC2805	Inhibitor	99.42%	Unkown
HY-168601	WWP1/2-IN-1	Inhibitor	/	Unkown
HY-180107	H36-E4	Inhibitor	98.57%	Unkown
HY-180108	H111-H7	Inhibitor	98.14%	Unkown
HY-RS15861	WWP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18265	Wwp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24744	Wwp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WWP2	VGNC	VGNC:67100
Rattus norvegicus	WWP2	RGD	RGD:1310091
Mus musculus	WWP2	MGD	MGI:1914144
Macaca mulatta	WWP2	VGNC	VGNC:103887
Canis familiaris	WWP2	VGNC	VGNC:48444
Bos taurus	WWP2	VGNC	VGNC:36979
Others	WWP2	NCBI