HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

ADC Targets in Oncology

2026-04-10

Species: Macaca mulatta

Gene Type: protein coding

Gene ID: 705479

About HMGCR

Primary_assembly 6: 72,212,759-72,239,535 forward strand.Mmul_10:CM014341.1

This gene has 2 transcripts (splice variants) and 206 orthologues.

HMGCR Products (2)

mRNA	Protein	Name
XM_002804417.3	XP_002804463.3	3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1
XM_001104607.4	XP_001104607.3	3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

HMGCR Protein Structure

2A060605

0
200
400
600
800
908 a.a.

Protein Preferred Names	Protein Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Protein Preferred Names

Protein Names

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17504	Rosuvastatin Calcium		99.77%	Yes
HY-17504B	Rosuvastatin Sodium		99.91%	Yes
HY-119695A	Simvastatin acid ammonium	Inhibitor	99.70%	Unkown
HY-115292	Simvastatin hydroxy acid sodium	Inhibitor	99.86%	Unkown
HY-119695	Simvastatin acid	Inhibitor	95.51%	Unkown
HY-119695B	Simvastatin acid calcium hydrate	Inhibitor	/	Unkown

Pre-clinical Phase

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107855	DL-Mevalonolactone		99.15%	Unkown
HY-15483	DY131		99.72%	Unkown
HY-N0466	Rebaudioside A		98.0%	Unkown
HY-N6712	Thiolutin	Inhibitor	99.27%	Unkown
HY-N0686	Pseudoprotodioscin	Inhibitor	99.17%	Unkown
HY-111355	Cholesterol sulfate		99.71%	Unkown
HY-135700	Mevalonolactone		98.0%	Unkown
HY-N0430A	Coptisine Sulfate		99.37%	Unkown
HY-17504R	Rosuvastatin Calcium (Standard)		99.94%	Unkown
HY-114316	HMG499	Inhibitor	96.12%	Unkown
HY-142026	Vitisin A		96%	Unkown
HY-106281	Bemfivastatin	Inhibitor	99.48%	Unkown
HY-106281A	Bemfivastatin hemicalcium	Inhibitor	98.00%	Unkown
HY-17504BS1	Rosuvastatin-d6 sodium	Inhibitor	99.9%	Unkown
HY-N0430	Coptisine		/	Unkown
HY-N11637	Ganoderenic acid K	Inhibitor	99.64%	Unkown
HY-RS06238	HMGCR Human Pre-designed siRNA Set A		/	Unkown
HY-17504BS2	Rosuvastatin-13C,d3 sodium		/	Unkown
HY-101873S	Atorvastatin lactone-d5	Inhibitor	/	Unkown
HY-107855S2	DL-Mevalonolactone-13C		/	Unkown
HY-107855S4	DL-Mevalonolactone-13C2		/	Unkown
HY-115292S	Simvastatin hydroxy acid-d6 sodium	Inhibitor	/	Unkown
HY-116241	L-157012	Inhibitor	/	Unkown
HY-119695AS1	Simvastatin acid-d9 ammonium	Inhibitor	/	Unkown
HY-147195	QH536	Inhibitor	/	Unkown
HY-171823	PROTAC HMGCR Degrader-1	Degrader	/	Unkown
HY-181134	PROTAC HMGCR Degrader-2		/	Unkown
HY-184354	NO-Pravastatin		/	Unkown
HY-N11637A	(Z)-Ganoderenic acid K	Control	/	Unkown
HY-N16439	Phenicin	Inhibitor	/	Unkown
HY-P11881	IUB288		/	Unkown
HY-P2985A	Alanine aminotransferase, Human liver		/	Unkown
HY-RS06239	Hmgcr Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06240	Hmgcr Rat Pre-designed siRNA Set A		/	Unkown
HY-W740010	N-Desmethyl rosuvastatin disodium hydrate		99.1%	Unkown
HY-W752587	DL-Mevalonolactone-d4		/	Unkown
HY-107855R	DL-Mevalonolactone (Standard)		/	Unkown
HY-119695S	Simvastatin acid-d6	Inhibitor	/	Unkown
HY-136345A	3'-Hydroxy simvastatin		99.71%	Unkown

Cat. No.

Product Name

Effect

Purity

Rare Diseases

HY-107855

DL-Mevalonolactone

99.15%

Unkown

HY-15483

DY131

99.72%