TIMP4 - TIMP metallopeptidase inhibitor 4 Gene

Also Known as TIMP-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7079

About TIMP4

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,153,068-12,158,912 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Biased expression in fat (RPKM 76.2) and brain (RPKM 10.2).

Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the Matrix Metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

TIMP4 Products (1)

mRNA Protein Name
NM_003256.4 NP_003247.1 metalloproteinase inhibitor 4 precursor

TIMP4 Protein Structure

TIMP

TIMP: Tissue inhibitor of metalloproteinase (28 - 207)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

metalloproteinase inhibitor 4

  • tissue inhibitor of metalloproteinase 4

Recombinant TIMP4 Proteins

Cat. No. Product Name Accession Purity
HY-P71368 TIMP-4 Protein, Human (HEK293, His) Q99727 (C30-P224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Corneal Neovascularization

  • Corneal Neovascularisation

  • Corneal Vascularisation

  • Extensive Superficial Corneal Vascularisation
Rheumatic Heart Disease

  • Rheumatic Carditis

  • Rheumatic Congestive Heart Failure

  • Congestive Rheumatic Heart Failure

  • Rheumatic Heart Failure

  • RHD

  • Rheumatic Fever Inactive Or Quiescent With Heart Disease

  • Rheumatic Fever Inactive Or Quiescent With Carditis

  • Organ Rheumatic Heart Disease

  • Organic Rheumatic Heart Disease

  • Inactive Rheumatic Heart Disease

  • Rheumatic Heart

  • Rheumatic Fever Inactive Or Quiescent With Pancarditis

  • Rhd - [Rheumatic Heart Disease]

  • Rheumatic Cardiac Hypertrophy

  • Rheumatic Fever

  • Inactive Or Quiescent With Cardiac Hypertrophy

  • Rheumatic Pancarditis

  • Inactive Rhd - [Rheumatic Heart Disease]

  • Rheumatic Nonischaemic Cardiopathy
Sorsby Fundus Dystrophy

  • SFD

  • Fundus Dystrophy, Pseudoinflammatory, Of Sorsby

  • Sorsby'S Fundus Dystrophy

  • Macular Dystrophy, Hemorrhagic

  • Hemorrhagic Macular Dystrophy

  • Pseudoinflammatory Fundus Dystrophy Of Sorsby

  • Sorsby'S Pseudoinflammatory Macular Dystrophy

  • Sorsby Pseudoinflammatory Fundus Dystrophy

  • Dystrophy, Fundus, Sorsby
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14541 TIMP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20115 Timp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26619 Timp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TIMP4 VGNC VGNC:47378
Mus musculus TIMP4 MGD MGI:109125
Rattus norvegicus TIMP4 RGD RGD:69077
Bos taurus TIMP4 VGNC VGNC:35873
Felis catus TIMP4 VGNC VGNC:66194
Macaca mulatta TIMP4 VGNC VGNC:78358
Others TIMP4 NCBI