TIMP4 - TIMP metallopeptidase inhibitor 4 Gene

Homo sapiens

Also known as TIMP-4

Gene ID: 7079 | Gene type: protein coding

About TIMP4

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,153,068-12,158,912 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Biased expression in fat (RPKM 76.2) and brain (RPKM 10.2).

Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the Matrix Metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

TIMP4 Products(1)

mRNA	Protein	Name
NM_003256.4	NP_003247.1	metalloproteinase inhibitor 4 precursor

TIMP4 Protein Structure

TIMP

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

metalloproteinase inhibitor 4

tissue inhibitor of metalloproteinase 4

Recombinant TIMP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71368	TIMP-4 Protein, Human (HEK293, His)	Q99727 (C30-P224)	≥95%

Related Diseases

Diseases

Alias

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Rheumatic Heart Disease

Rheumatic Carditis	Rheumatic Congestive Heart Failure
Congestive Rheumatic Heart Failure	Rheumatic Heart Failure
RHD	Rheumatic Fever Inactive Or Quiescent With Heart Disease
Rheumatic Fever Inactive Or Quiescent With Carditis	Organ Rheumatic Heart Disease
Organic Rheumatic Heart Disease	Inactive Rheumatic Heart Disease
Rheumatic Heart	Rheumatic Fever Inactive Or Quiescent With Pancarditis
Rhd - [Rheumatic Heart Disease]	Rheumatic Cardiac Hypertrophy
Rheumatic Fever	Inactive Or Quiescent With Cardiac Hypertrophy
Rheumatic Pancarditis	Inactive Rhd - [Rheumatic Heart Disease]
Rheumatic Nonischaemic Cardiopathy

Sorsby Fundus Dystrophy

SFD	Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Sorsby'S Fundus Dystrophy	Macular Dystrophy, Hemorrhagic
Hemorrhagic Macular Dystrophy	Pseudoinflammatory Fundus Dystrophy Of Sorsby
Sorsby'S Pseudoinflammatory Macular Dystrophy	Sorsby Pseudoinflammatory Fundus Dystrophy
Dystrophy, Fundus, Sorsby

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14541	TIMP4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIMP4	VGNC	VGNC:47378
Mus musculus	TIMP4	MGD	MGI:109125
Rattus norvegicus	TIMP4	RGD	RGD:69077
Bos taurus	TIMP4	VGNC	VGNC:35873
Felis catus	TIMP4	VGNC	VGNC:66194
Macaca mulatta	TIMP4	VGNC	VGNC:78358
Others	TIMP4	NCBI

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