SERPING1 - serpin family G member 1 Gene

Homo sapiens

Also known as C1IN; C1NH; HAE1; HAE2; C1INH

Gene ID: 710 | Gene type: protein coding

About SERPING1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,597,685-57,614,848 (from NCBI)

This gene has 22 transcripts (splice variants), 191 orthologues, 36 paralogues and is associated with 4 phenotypes. Broad expression in liver (RPKM 710.5), gall bladder (RPKM 322.8) and 17 other tissues.

Summary

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020]

SERPING1 Products(2)

mRNA	Protein	Name
NM_000062.3	NP_000053.2	plasma protease C1 inhibitor precursor
NM_001032295.2	NP_001027466.1	plasma protease C1 inhibitor precursor

SERPING1 Protein Structure

Serpin

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

plasma protease C1 inhibitor

C1 esterase inhibitor

Recombinant SERPING1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71296	Serpin G1 Protein, Human (478a.a, HEK293, His)	AAH11171.1 (N23-A500)	≥95%
HY-P73526	Serpin G1 Protein, Human (500a.a, HEK293, His)	P05155/NP_000053.2 (N23-A500)	≥95%

Related Diseases

Diseases

Alias

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Complement Component 4, Partial Deficiency Of

Angioedemas, Hereditary

C1 Inhibitor Deficiency

Quincke Edema	Angioedemas, Hereditary
Angioedema

Hereditary Angioedema With C1inh Deficiency

Hae With C1 Inhibitor Deficiency	Hae With C1inh Deficiency
Hereditary Angioneurotic Edema With C1 Inhibitor Deficiency	Hereditary Angioneurotic Edema With C1inh Deficiency

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Acquired Angioedema

Acquired C1 Inhibitor Deficiency	Angioedema, Acquired
Aae	Acquired Angioneurotic Edema
Acquired Bradykinine-Induced Angioedema	Acquired Non Histamine-Induced Angioedema
Acquired Angioneurotic Oedema	Aae - [Acquired Angioneurotic Oedema]

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Angioedema, Hereditary, 3

Angioedema, Hereditary, Type Iii	Hereditary Angioedema Type Iii
Hereditary Angioedema Type 3	HAE3
Estrogen-Related Hae	Estrogen-Sensitive Hae
Angioneurotic Edema, Hereditary, With Normal C1 Inhibitor Concentration And Function	Hae With Normal C1 Inhibitor Concentration And Function
Hereditary Angioedema With Normal C1 Inhibitor Activity	F12-Related Hereditary Angioedema With Normal C1inh
F12-Related Hae With Normal C1 Inhibitor	Hae 3
Hae-Iii	Hereditary Angioneurotic Edema Type 3
Inherited Estrogen-Associated Angioedema	Inherited Estrogen-Associated Angioneurotic Edema
Inherited Estrogen-Dependent Angioedema	Inherited Estrogen-Dependent Angioneurotic Edema
Angioneurotic Edema Hereditary With Normal C1 Inhibitor Concentration And Function	Hereditary Angioedema With Normal C1 Esterase Inhibitor Activity

Physical Urticaria

Symptomatic Dermographism

Cholinergic Urticaria

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Louse-Borne Relapsing Fever

Relapsing Fever, Louse-Borne

Relapsing Fever Due To Borrelia Recurrentis

Melkersson-Rosenthal Syndrome

Melkersson Syndrome	Mros
Mrs	Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal
Melkersson'S Syndrome	Cheilitis Granulomatosa
Granulomatous Cheilitis

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Complement Deficiency

Complement Deficiency Disease

Hereditary Complement Deficiency Diseases

Fissured Tongue

Furrowed Tongue	Plicated Tongue
Tongue, Fissured	Congenital Fissure Of Tongue
Congenital Plicated Tongue	Fissure Of Tongue
Fissure Of Tongue, Congenital	Geographic Tongue And Fissured Tongue
Lingua Plicata	Scrotal Tongue

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Allergic Urticaria

Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis

Tick-Borne Relapsing Fever

Relapsing Fever, Tick-Borne	Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis
African Tick-Borne Fever

Chronic Inducible Urticaria

Capillary Leak Syndrome

Systemic Capillary Leak Syndrome	Clarkson Disease
Capillary Leak Syndrome With Monoclonal Gammopathy	Scls
Periodic Systemic Capillary Leak Syndrome	Capillary Hyperpermeability Syndrome
Idiopathic Capillary Leak Syndrome

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Integumentary System Disease

Capillary Disease

Disease Of Capillaries

Cecal Disease

Cecal Diseases

Disorder Of Cecum

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Alpha-2-Plasmin Inhibitor Deficiency

Plasmin Inhibitor Deficiency	Antiplasmin Deficiency
Antiplasmin Defiency	Anti-Plasmin Deficiency, Congenital
Antiplasmin Deficiency, Congenital	Congenital Alpha2-Antiplasmin Deficiency
APLID	Congenital Alpha2 Antiplasmin Deficiency

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12694	SERP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERPING1	MGD	MGI:894696
Felis catus	SERPING1	VGNC	VGNC:65029
Bos taurus	SERPING1	VGNC	VGNC:54891
Rattus norvegicus	SERPING1	RGD	RGD:735225
Macaca mulatta	SERPING1	VGNC	VGNC:77223
Canis familiaris	SERPING1	VGNC	VGNC:52042
Others	SERPING1	NCBI