2. Gene
  3. C4BPA - complement component 4 binding protein alpha Gene

C4BPA - complement component 4 binding protein alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRP; C4BP

Gene ID: 722 | Gene type: protein coding

About C4BPA

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:207,104,233-207,144,972 (from NCBI)

This gene has 3 transcripts (splice variants), 146 orthologues and 39 paralogues. Biased expression in liver (RPKM 372.5) and lung (RPKM 75.1).

Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 Amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

C4BPA Products(1)

mRNA Protein Name
NM_000715.4 NP_000706.1 C4b-binding protein alpha chain precursor

C4BPA Protein Structure

Sushi

Sushi: Sushi repeat (SCR repeat) (50 - 105)

Sushi

Sushi: Sushi repeat (SCR repeat) (113 - 170)

Sushi

Sushi: Sushi repeat (SCR repeat) (175 - 234)

Sushi

Sushi: Sushi repeat (SCR repeat) (239 - 294)

Sushi

Sushi: Sushi repeat (SCR repeat) (299 - 357)

Sushi

Sushi: Sushi repeat (SCR repeat) (365 - 422)

Sushi

Sushi: Sushi repeat (SCR repeat) (426 - 480)

Sushi

Sushi: Sushi repeat (SCR repeat) (484 - 538)

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  • 597 a.a.
Protein Preferred Names Protein Names

C4b-binding protein alpha chain

proline-rich protein

Related Diseases

Diseases Alias
Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01747 C4BPA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus C4BPA RGD RGD:2235
Bos taurus C4BPA VGNC VGNC:103055
Macaca mulatta C4BPA VGNC VGNC:70474
Canis familiaris C4BPA VGNC VGNC:38593