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Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

Also Known as p53Lyn; p56Lyn

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81515

Summary

Enables several functions, including gamma-tubulin binding activity; signaling receptor binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including histamine secretion by mast cell; neurogenesis; and positive regulation of Fc receptor mediated stimulatory signaling pathway. Located in several cellular components, including adherens junction; mitochondrial envelope; and postsynaptic density. Part of Integrin alpha2-beta1 complex. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Biomarker of Parkinsonism and endometriosis. Orthologous to human Lyn (Lyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lyn Products (2)

mRNA	Protein	Name
NM_001111098.1	NP_001104568.1	tyrosine-protein kinase Lyn isoform B
NM_030857.2	NP_110484.1	tyrosine-protein kinase Lyn isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	8190127	RGD
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	10545487	RGD
enables glycosphingolipid binding	IPI IPI: Inferred from physical interaction	8106508	RGD
enables integrin binding	IDA IDA: Inferred from direct assay	15504915	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	8910399	RGD
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	15504915	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10944523	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12007793	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17579026	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12681493	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	8870703	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	14531861	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	12372808	RGD
involved in histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	16177098	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	15504915	RGD
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	16177098	RGD
involved in positive regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	15504915	RGD
involved in positive regulation of oligodendrocyte progenitor proliferation	IMP IMP: Inferred from mutant phenotype	15504915	RGD
involved in positive regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	16177098	RGD
involved in regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	16177098	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	16529858	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	17918263	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	10330413	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	12089355	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15287886	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	16713446	RGD
involved in response to sterol depletion	IEP IEP: Inferred from expression pattern	10330413	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16529858	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17039281	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	1709169	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14529711	RGD
part of integrin alpha2-beta1 complex	IDA IDA: Inferred from direct assay	18234883	RGD
located in mitochondrial crista	IDA IDA: Inferred from direct assay	12007793	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	12007793	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10545487	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	14529711	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein kinase Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog lyn protein non-receptor kinase v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12039	Lyn-IN-1	Inhibitor	98.07%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-125142	AP-24567	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-187803	Tyrosine kinase-IN-12	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lyn	NCBI	NCBI:4067