Myoc - myocilin Gene

Also Known as Tigr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81523

Summary

Predicted to enable fibronectin binding activity; Myosin light chain binding activity; and signaling receptor binding activity. Involved in cellular response to nerve growth factor stimulus and nerve development. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath abaxonal region. Biomarker of membranoproliferative glomerulonephritis and ocular hypertension. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Apr 2022]

Myoc Products (1)

mRNA Protein Name
NM_030865.2 NP_110492.2 myocilin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
17663725 RGD
involved in nerve development IEP
IEP: Inferred from expression pattern
12838505 RGD
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
12838505 RGD
located in mesaxon IDA
IDA: Inferred from direct assay
12838505 RGD
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
12838505 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocilin

  • myocilin, trabecular meshwork inducible glucocorticoid response

  • trabecular meshwork-induced glucocorticoid response protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08954 MYOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20300 Myoc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26808 Myoc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myoc NCBI NCBI:4653