PROK1 - prokineticin 1 Gene

Also Known as PK1; PRK1; EGVEGF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84432

About PROK1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,451,149-110,457,358 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 1 paralogue. Biased expression in ovary (RPKM 72.8), testis (RPKM 51.2) and 2 other tissues.

Summary

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of Other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

PROK1 Products (1)

mRNA Protein Name
NM_032414.3 NP_115790.1 prokineticin-1 precursor

PROK1 Protein Structure

Prokineticin

Prokineticin: Prokineticin (1 - 97)

  • 0
  • 100
  • 105 a.a.
Protein Preferred Names Protein Names

prokineticin-1

  • EG-VEGF

Recombinant PROK1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71906 Prokineticin-1/EG-VEGF Protein, Human P58294 (A20-F105) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74616 Prokineticin-1/EG-VEGF Protein, Human (sf9, His) P58294 (A20-F105) ≥ 90%, as determined by reducing SDS-PAGE.

PROK1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83246 EG VEGF Antibody (YA2991) WB, FC Human, Mouse

Related Diseases

Diseases Alias
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Endocervicitis
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11194 PROK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21031 Prok1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21699 Prok2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27548 Prok1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PROK1 MGD MGI:2180370
Macaca mulatta PROK1 VGNC VGNC:76284
Felis catus PROK1 VGNC VGNC:80324
Rattus norvegicus PROK1 RGD RGD:620898
Canis familiaris PROK1 VGNC VGNC:45010
Bos taurus PROK1 VGNC VGNC:33361
Others PROK1 NCBI