MYO18B - myosin XVIIIB Gene

Also Known as KFS4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84700

About MYO18B

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:25,742,188-26,063,847 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 43 paralogues and is associated with 3 phenotypes. Biased expression in heart (RPKM 11.4) and testis (RPKM 1.5).

Summary

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung Cancer. [provided by RefSeq, Jul 2008]

MYO18B Products (2)

mRNA	Protein	Name
NM_001318245.2	NP_001305174.1	unconventional myosin-XVIIIb isoform 1
NM_032608.7	NP_115997.5	unconventional myosin-XVIIIb isoform 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
part of unconventional myosin complex	IDA IDA: Inferred from direct assay	12547197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO18B Protein Structure

Myosin_head

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2567 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-XVIIIb	myosin 18B

MYO18B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810826	MYO18B Antibody (YA10069)	WB, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Klippel-Feil Syndrome 4, Autosomal Recessive, With Nemaline Myopathy And Facial Dysmorphism	Klippel-Feil Anomaly-Myopathy-Facial Dysmorphism Syndrome KFS4 Klippel-Feil Syndrome 4, Autosomal Recessive, With Myopathy And Facial Dysmorphism
Klippel-Feil Syndrome	Cervical Vertebral Fusion Congenital Dystrophia Brevicollis Cervical Fusion Syndrome Klippel-Feil Deformity Autosomal Dominant Klippel-Feil Syndrome Congenital Synostosis Of Cervical Vertebrae Klippel-Feil And Turner Syndrome Klippel-Feil Deformity, Deafness And Facial Asymmetry Klippel Feil Syndrome Cervical Vertebral Fusion Syndrome Dystrophia Brevicollis Congenita Fusion Of Cervical Vertebrae Kfs Klippel-Feil Sequence Vertebral Cervical Fusion Syndrome Klippel-Feil Syndrome, Autosomal Dominant Klippel-Feil Malformation Isolated Klippel-Feil Syndrome
Klippel-Feil Syndrome 2, Autosomal Recessive	Klippel-Feil Syndrome 2 KFS2 Cervical Vertebral Fusion Autosomal Recessive Kfs, Autosomal Recessive Cervical Vertebral Fusion, Autosomal Recessive Kfs Autosomal Recessive Klippel-Feil Syndrome, Type 2, Autosomal Recessive Klippel Feil Syndrome Recessive Type
Klippel-Feil Syndrome 4
Klippel-Feil Syndrome 1, Autosomal Dominant	KFS1 Cervical Vertebral Fusion Autosomal Dominant Kfs Cervical Vertebral Fusion, Autosomal Dominant Cervical Vertebral Fusion Congenital Congenital Klippel-Feil Segment Fused Cervical Segments Congenital Isolated Klippel-Feil Syndrome Klippel-Feil Malformation Klippel-Feil Sequence Klippel-Feil Syndrome, Type 1, Autosomal Dominant Klippel-Feil Syndrome, Autosomal Dominant
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dyslexia
Myopathy	Muscular Diseases Myopathies
Myopathy, Congenital, Bailey-Bloch	Native American Myopathy Nam MYPBB Myopathy, Congenital, Baily-Bloch Anti-Hmg-Coa Myopathy Anti-Srp Myopathy Autoimmune Necrotizing Myositis Imnm Immune Myopathy With Myocyte Necrosis Immune-Mediated Necrotizing Myopathy Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia Necrotizing Autoimmune Myopathy Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
Dyscalculia	Disorder Of Arithmetical Skills Mathematics Disorder Developmental Arithmetic Disorder
Congenital Structural Myopathy
Multiple Pterygium Syndrome, Escobar Variant	Multiple Pterygium Syndrome Pterygium Escobar Syndrome EVMPS Pterygium Syndrome Autosomal Recessive Multiple Pterygium Syndrome Pterygium Colli Syndrome Pterygium Universale Autosomal Recessive Non-Lethal Multiple Pterygium Syndrome Escobar Variant Multiple Pterygium Syndrome Multiple Pterygium Syndrome, Nonlethal Type Surfer'S Eye Multiple Pterygium Syndrome Escobar Type Multiple Pterygium Syndrome Nonlethal Type Familial Pterygium Syndrome Pterygium Colli Multiple Pterygium Syndrome, Non-Lethal Type Nonlethal Type Multiple Pterygium Syndrome Pterygium Syndrome, Multiple, Escobar Type Pterygium Of Eye Web Eye
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08935	MYO18B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYO18B	VGNC	VGNC:82549
Canis familiaris	MYO18B	VGNC	VGNC:43558
Bos taurus	MYO18B	VGNC	VGNC:31814
Macaca mulatta	MYO18B	VGNC	VGNC:74985
Rattus norvegicus	MYO18B	RGD	RGD:1594542
Mus musculus	MYO18B	MGD	MGI:1921626
Others	MYO18B	NCBI