Rpe65 - retinoid isomerohydrolase RPE65 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89826

Summary

Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Apr 2022]

Rpe65 Products (1)

mRNA Protein Name
NM_053562.3 NP_446014.2 retinoid isomerohydrolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IMP
IMP: Inferred from mutant phenotype
21785167 RGD
Biological Process GO Annotation Evidence References Source
involved in camera-type eye development IEP
IEP: Inferred from expression pattern
9512345 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12742352 RGD
involved in neural retina development IDA
IDA: Inferred from direct assay
2631392 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
17389522 RGD
involved in retinal metabolic process IMP
IMP: Inferred from mutant phenotype
21785167 RGD
involved in retinol metabolic process IDA
IDA: Inferred from direct assay
3603006 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
19180257 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoid isomerohydrolase

  • RPE65, retinoid isomerohydrolase

  • all-trans-retinyl-palmitate hydrolase

  • lutein isomerase

  • meso-zeaxanthin isomerase

  • retinal pigment epithelium 65

  • retinal pigment epithelium 65-like

  • retinal pigment epithelium-specific 65 kDa protein

  • retinal pigment ep

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19720A Emixustat hydrochloride Inhibitor 99.29% Phase 3

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19720 Emixustat 98.00% Yes
HY-149325 RPE65-IN-1 Inhibitor ≥98.0% Unkown
HY-119059 CU239 Inhibitor / Unkown
HY-175663 EYE-002 Inhibitor / Unkown
HY-175664 EYE-003 Inhibitor / Unkown
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29294 Rpe65 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpe65 NCBI NCBI:6121