HMGN3 - high mobility group nucleosomal binding domain 3 Gene

Also Known as TRIP7; PNAS-24; PNAS-25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9324

About HMGN3

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:79,201,245-79,234,682 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 45.8), adrenal (RPKM 40.5) and 25 other tissues.

Summary

The protein encoded by this gene binds Thyroid Hormone Receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]

HMGN3 Products (9)

mRNA Protein Name
NM_001201362.2 NP_001188291.1 high mobility group nucleosome-binding domain-containing protein 3 isoform c
NM_001201363.2 NP_001188292.1 high mobility group nucleosome-binding domain-containing protein 3 isoform d
NM_001318884.2 NP_001305813.1 high mobility group nucleosome-binding domain-containing protein 3 isoform e
NM_001318885.2 NP_001305814.1 high mobility group nucleosome-binding domain-containing protein 3 isoform f
NM_001318886.2 NP_001305815.1 high mobility group nucleosome-binding domain-containing protein 3 isoform g
NM_001318887.2 NP_001305816.1 high mobility group nucleosome-binding domain-containing protein 3 isoform h
NM_001318888.2 NP_001305817.1 high mobility group nucleosome-binding domain-containing protein 3 isoform i
NM_004242.4 NP_004233.1 high mobility group nucleosome-binding domain-containing protein 3 isoform a
NM_138730.3 NP_620058.1 high mobility group nucleosome-binding domain-containing protein 3 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
33468658 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGN3 Protein Structure

HMG14_17

HMG14_17: HMG14 and HMG17 (2 - 96)

  • 0
  • 99 a.a.
Protein Preferred Names Protein Names

high mobility group nucleosome-binding domain-containing protein 3

  • TR-interacting protein 7

Recombinant HMGN3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75810 HMGN3 Protein, Human (His) Q15651-2 (M1-N77) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06245 HMGN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19205 Hmgn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25693 Hmgn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HMGN3 RGD RGD:1359106
Bos taurus HMGN3 VGNC VGNC:49985
Mus musculus HMGN3 MGD MGI:2138069
Canis familiaris HMGN3 VGNC VGNC:57223
Macaca mulatta HMGN3 VGNC VGNC:73385
Others HMGN3 NCBI