MPMS-VA
MPMS-VA is a highly hydrophilic peptide cleavable linker that can be used for the construction of ADCs. MPMS-VA can be cleaved at the Val-Ala site by lysosomal cathepsin B in tumor cells. MPMS-VA can enhance the hydrophilicity of the antibody-drug conjugate linker-payload system. MPMS-VA improves the plasma stability of relevant ADCs and reduces the systemic release of free payload. MPMS-VA can be applied in research related to solid tumors with co-expression of EGFR/HER2, such as lung cancer, breast cancer, gastric cancer, and urothelial carcinoma.
For research use only. We do not sell to patients.
- Formula: C39H65N5O16S
- Molecular Weight:892.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MPMS-VA, a highly hydrophilic peptide-based cleavable linker for GenSci139, preserves the integrity of the conjugated ADC and the homogeneous DAR distribution in plasma in vitro, and is specifically cleaved by lysosomal cathepsin B in tumor cells to release the topoisomerase I inhibitor payload GSC5181[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 892.02
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Formula C39H65N5O16S
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SMILES
OC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC#CC1=CN=C(S(=O)(C)=O)N=C1OC)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPMS-VA Related Classifications
HY-189203 Related Classifications
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