PROTACs Control
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SA-PA
0 ImagesCat. No.: HY-155684CAS No.: 3058085-76-7SA-PA is a synthetic self-assembling proteolysis-targeting chimera (PROTAC), which is generated via an intracellular copper ion-catalyzed click chemical reaction between SA and PA. SA-PA cannot mediate the degradation of VEGFR‑2 and EphB4 proteins, but still exhibits proliferation inhibitory activity against U87 and A549 cells. SA‑PA can be used in cancer-related research.
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PROTAC SGK3 degrader-2
0 ImagesCat. No.: HY-176823CAS No.: 2381196-78-5PROTAC SGK3 degrader-2 is the cis epimer of PROTAC SGK3 degrader-1 (SGK3-PROTAC1) (HY-125878). PROTAC SGK3 degrader-2 exhibits inhibitory activity against SGK3, SGK1 and S6K1, with IC50 values of 0.6 μM, 1.4 μM and 1.7 μM, respectively, but fails to degrade SGK3. PROTAC SGK3 degrader-2 can serve as a control compound to investigate the specific effects of SGK3 degradation mediated by SGK3-PROTAC1.
