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LGALS7 - galectin 7 Gene

Also Known as GAL7; LGALS7A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3963

About LGALS7

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,770,968-38,773,517 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 328 orthologues and 16 paralogues. Restricted expression toward skin (RPKM 300.6).

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

LGALS7 Products (1)

mRNA	Protein	Name
NM_002307.4	NP_002298.1	galectin-7

LGALS7 Protein Structure

Gal-bind_lectin

0
100
136 a.a.

Protein Preferred Names	Protein Names
galectin-7	lectin, galactoside-binding, soluble, 7

LGALS7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LGALS7	P47929	TGM5	Homo sapiens	O43548	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	TGM5	Homo sapiens	O43548	Y2H Array	32296183
Intra	LGALS7	P47929	YAF2	Homo sapiens	Q8IY57-5	Validated Y2H	32296183
Intra	LGALS7	P47929	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	LGALS7	P47929	LSM2	Homo sapiens	Q9Y333	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	LGALS7	P47929	LSM2	Homo sapiens	Q9Y333	Y2H Array	32296183
Intra	LGALS7	P47929	SSBP1	Homo sapiens	Q04837	Validated Y2H	32296183
Intra	LGALS7	P47929	SSBP1	Homo sapiens	Q04837	Y2H Array	32296183
Intra	LGALS7	P47929	SSBP1	Homo sapiens	Q04837	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	HSPA6	Homo sapiens	P17066	Y2H Array	32296183
Intra	LGALS7	P47929	HSPA6	Homo sapiens	P17066	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	TAB1	Homo sapiens	Q15750	Y2H Prey Pooling	32296183
Intra	LGALS7	P47929	TAB1	Homo sapiens	Q15750	Validated Y2H	32296183
Intra	LGALS7	P47929	TAB1	Homo sapiens	Q15750	Y2H Array	32296183
Intra	LGALS7	P47929	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	LGALS7	P47929	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	LGALS7	P47929	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70358	Galectin-7/LGALS7 Protein, Human	P47929 (M1-F136)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73071	Galectin-7/LGALS7 Protein, Human (GST)	P47929 (S2-F136)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700080AF	Animal-Free Galectin-7/LGALS7 Protein, Human (His)	P47929 (S2-F136)	≥ 95%, as determined by reducing SDS-PAGE.

LGALS7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82200	Galectin 7 Antibody (YA1945)	WB, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Esophageal Basaloid Squamous Cell Carcinoma	Basaloid Squamous Carcinoma Of Esophagus Esophageal Basaloid Carcinoma
Galactosemia I	Galactosemia Galt Deficiency Classic Galactosemia Galactose-1-Phosphate Uridylyltransferase Deficiency Galactose-1-Phosphate Uridyltransferase Deficiency GALAC1 Galactosemia, Classic Galactosemia Type 1 Galactosemias Classical Galactosemia Galactosaemia Galactose Intolerance Epimerase Deficiency Galactosemia Galactokinase Deficiency Disease Galactose Epimerase Deficiency Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease Gale Deficiency Galk Deficiency Udp-Galactose-4-Epimerase Deficiency Disease Utp Hexose-1-Phosphate Uridylyltransferase Deficiency Galactosemia 1 Galactosemia, Duarte Variant Deficiency Of Galactokinase Udpglucose 4-Epimerase Deficiency Disease Classical Galactosaemia Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency Classic Galactosaemia Deficiency Of Hexose-1-Phosphate Uridylyltransferase Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase Deficiency Of Galactose-1-Phosphate Uridylyltransferase Galactose-1-Phosphate Uridyl Transferase Deficiency Transferase Deficiency Galactosemia Deficiency Of Uridyl Transferase Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Bladder Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Bladder Epidermoid Carcinoma Of The Urinary Bladder Carcinoma Squamous Cell Bladder
Amyloid Tumor	Amyloid Neoplasm Amyloid Tumour
Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ	Carcinoma In Situ Of Cervix Carcinoma In Situ Of Uterine Cervix Cervical Intraepithelial Neoplasia Carcinoma Of Cervix Stage 0 Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia Cervix Ca In Situ Cin Iii Cin Iii - Carcinoma In Situ Of Cervix Cin Iii - Severe Dyskaryosis Severe Dysplasia Of Cervix Severe Dysplasia Of The Cervix Uteri Squamous Intraepithelial Neoplasia, Grade Iii Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07607	LGALS7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07608	LGALS7B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19264	Lgals7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25753	Lgals7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGALS7	RGD	RGD:61951
Mus musculus	LGALS7	MGD	MGI:1316742