country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

C1QC - complement C1q C chain Gene

Also Known as C1QG; C1Q-C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 714

About C1QC

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,643,633-22,648,108 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 519.1), lymph node (RPKM 141.4) and 14 other tissues.

Summary

This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

C1QC Products (4)

mRNA	Protein	Name
NM_001114101.3	NP_001107573.1	complement C1q subcomponent subunit C isoform 1 precursor
NM_001347619.2	NP_001334548.1	complement C1q subcomponent subunit C isoform 1 precursor
NM_001347620.2	NP_001334549.1	complement C1q subcomponent subunit C isoform 2
NM_172369.5	NP_758957.2	complement C1q subcomponent subunit C isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28018340	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in complement activation, classical pathway	IDA IDA: Inferred from direct assay	29449492	GOA
involved in negative regulation of granulocyte differentiation	IDA IDA: Inferred from direct assay	10961870	GOA
involved in negative regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	10961870	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of complement component C1q complex	IPI IPI: Inferred from physical interaction	29449492	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18250442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QC Protein Structure

Collagen

C1q

0
100
200
245 a.a.

Protein Preferred Names	Protein Names
complement C1q subcomponent subunit C	complement component 1, q subcomponent, C chain

C1QC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	C1QC	P02747	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	ELISA	28018340
Intra	C1QC	P02747	ZNF534	Homo sapiens	Q76KX8	Validated Y2H	32296183
Intra	C1QC	P02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QC	P02747	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	C1QC	P02747	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
C1q Deficiency	C1QD Complement Component C1q Deficiency
Immunodeficiency Due To A Classical Component Pathway Complement Deficiency	Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency Immunodeficiency Due To An Early Component Of Complement Deficiency
Glomerulonephritis	Bright'S Disease
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Angioedema, Hereditary, 1	Hereditary Angioedema Type I Hereditary Angioneurotic Edema Hane C1 Esterase Inhibitor Deficiency Angioedema, Hereditary, 1 And 2 HAE1 Angioneurotic Edema, Hereditary Angioedema, Hereditary, Type I Hereditary Angioedema Type 2 Hae 2 Hae-Ii Hereditary Angioneurotic Edema Type 2 Angioedema, Hereditary HAE Angioedema, Hereditary, Types I And Ii Hereditary Angioedema, Type Ii Angioedema, Hereditary, Type 1 Angioedemas, Hereditary Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01721	C1QC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19879	C1qc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26378	C1qc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1QC	VGNC	VGNC:52112
Bos taurus	C1QC	VGNC	VGNC:26619
Macaca mulatta	C1QC	VGNC	VGNC:99857
Rattus norvegicus	C1QC	RGD	RGD:1306828
Mus musculus	C1QC	MGD	MGI:88225
Felis catus	C1QC	VGNC	VGNC:107491
Others	C1QC	NCBI