CCN3 - cellular communication network factor 3 Gene

Also Known as NOV; NOVh; IBP-9; IGFBP9; IGFBP-9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4856

About CCN3

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,416,446-119,424,434 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 5 paralogues. Biased expression in adrenal (RPKM 648.6) and prostate (RPKM 11.0).

Summary

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and Cancer development. [provided by RefSeq, Feb 2009]

CCN3 Products (1)

mRNA Protein Name
NM_002514.4 NP_002505.1 CCN family member 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Notch binding IPI
IPI: Inferred from physical interaction
12050162 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
12695522 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9927660 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
12695522 GOA
involved in cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
12695522 GOA
involved in cell chemotaxis IDA
IDA: Inferred from direct assay
15611078 GOA
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21871891 GOA
involved in endothelial cell chemotaxis IDA
IDA: Inferred from direct assay
12695522 GOA
involved in endothelial cell-cell adhesion IDA
IDA: Inferred from direct assay
12695522 GOA
involved in fibroblast migration IDA
IDA: Inferred from direct assay
15611078 GOA
involved in hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
17463287 GOA
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
15181016 GOA
involved in negative regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
21871891 GOA
involved in negative regulation of monocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
21063504 GOA
involved in negative regulation of myotube differentiation IDA
IDA: Inferred from direct assay
12050162 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21063504 GOA
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
12050162 GOA
involved in positive regulation of ossification IDA
IDA: Inferred from direct assay
38987585 GOA
involved in smooth muscle cell migration IDA
IDA: Inferred from direct assay
20139355 GOA
involved in smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
20139355 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
15181016 GOA
located in gap junction IMP
IMP: Inferred from mutant phenotype
15181016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCN3 Protein Structure

IGFBP

IGFBP: Insulin-like growth factor binding protein (35 - 89)

VWC

VWC: von Willebrand factor type C domain (110 - 173)

TSP_1

TSP_1: Thrombospondin type 1 domain (209 - 249)

Cys_knot

Cys_knot: Cystine-knot domain (262 - 347)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

CCN family member 3

  • IGF-binding protein 9

CCN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCN3 P48745 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra
CCN3 P48745 RECK Homo sapiens Q6P9E2
Validated Y2H
32296183
Intra
CCN3 P48745 NID2 Homo sapiens Q8IV28
Validated Y2H
32296183
Intra
CCN3 P48745 APOL6 Homo sapiens Q9BWW8
Validated Y2H
32296183
Intra
CCN3 P48745 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra
CCN3 P48745 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
CCN3 P48745 POU4F2 Homo sapiens Q12837
Validated Y2H
32296183
Intra
CCN3 P48745 TNIP3 Homo sapiens Q96KP6
Validated Y2H
32296183
Intra
CCN3 P48745 MACO1 Homo sapiens Q8N5G2
Validated Y2H
32296183
Intra
CCN3 P48745 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra
CCN3 P48745 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
CCN3 P48745 LCE3D Homo sapiens Q9BYE3
Validated Y2H
32296183
Intra
CCN3 P48745 C11orf87 Homo sapiens Q6NUJ2
Validated Y2H
32296183
Intra
CCN3 P48745 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Intra
CCN3 P48745 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
CCN3 P48745 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
CCN3 P48745 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor 5

  • Wilms Tumor

  • WT5

  • Wilms Tumor Susceptibility-5

  • Wilms Tumor And Radial Bilateral Aplasia

  • Nephroblastoma

  • Wilms' Tumor

  • Wilms Tumor, Susceptibility To

  • Wtsl

  • Bilateral Radial Aplasia With Wilms Tumor

  • Embryonal Adenosarcoma

  • Embryonal Nephroma

  • Kidney Wilms Tumor

  • Kidney, Adenomyosarcoma, Embryonal

  • Kidney, Carcinosarcoma, Embryonal

  • Kidney, Embryoma

  • Kidney, Embryonal Mixed Tumor

  • Nephroma

  • Renal Adenosarcoma

  • Renal Cancer, Wilms

  • Renal Wilms Tumor

  • Tumor, Wilms

  • Hereditary Susceptibility To Wilms Tumor 5
Rhabdomyosarcoma
Marfan Syndrome

  • MFS

  • Mfs1

  • Marfan'S Syndrome

  • Marfan Syndrome Type 1

  • Marfan Syndrome, Type I

  • Mass Phenotype

  • Contractural Arachnodactyly

  • Mass Syndrome

  • Octd

  • Overlap Connective Tissue Disease

  • Marfanoid Hypermobility Syndrome

  • Marfan Disease
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02112 CCN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17879 Ccn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24348 Ccn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CCN3 RGD RGD:621553
Mus musculus CCN3 MGD MGI:109185
Felis catus CCN3 VGNC VGNC:68520
Bos taurus CCN3 VGNC VGNC:57785
Macaca mulatta CCN3 VGNC VGNC:70932
Canis familiaris CCN3 VGNC VGNC:56074
Others CCN3 NCBI