Lincomycin hydrochloride
Based on 5 publication(s) in Google Scholar
Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 859-18-7
- Formula: C18H35ClN2O6S
- Molecular Weight:443.00
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Lincomycin hydrochloride
MoreAll DNA/RNA Synthesis Isoforms
MoreAll Antibiotic Isoforms
More
Biological Activity
Lincomycin (0.5-10 μg/mL; 10 days) hydrochloride can enhance the biosynthesis of actinorhodin and undecylprodigiosin in liquid-cultured Streptomyces coelicolor A3(2) 1147[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR (6-week-old male)[3]
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Dosage:33 mg/kg
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Administration:p.o.; ad libitum daily; 8 weeks
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Result:Resulted in a significant
increase in growth rate of mice (50.11 %) over an 8 weeks period.
Caused suppression in inflammatory response.
Exhibited altered lipid profiles and liver damage suggestive of early-stage non-alcoholic fatty liver disease (NAFLD).
Chemical Information
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CAS No. 859-18-7
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Appearance Solid
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Molecular Weight 443.00
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Formula C18H35ClN2O6S
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Color White to off-white
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SMILES
C[C@@H](O)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl
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Synonyms
U10149A
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Initial Source
Streptomyces lincolnensis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Targeting Peptostreptococcus anaerobius with an Iron-Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer. [Abstract]2026 Jan 12:e16272. PMID: 41524179 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
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Microb Biotechnol
Attenuator LRR - a regulatory tool for modulating gene expression in Gram-positive bacteria. [Abstract]2021 Nov;14(6):2538-2551. PMID: 33720523 -
Microbiol Spectr
2025 Aug 29:e0059025. PMID: 40879403
Solvent & Solubility
H2O : 100 mg/mL (225.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Griaznova, N.S., et al., [Effect of lincomycin and other protein synthesis inhibitors on the metabolism of Actinomyces roseolus, a producer of lincomycin]. Antibiotiki, 1980. 25(4): p. 250-6. [Content Brief]
[2]. Hummel, H., W. Piepersberg, and A. Bock, Analysis of lincomycin resistance mutations in Escherichia coli. Mol Gen Genet, 1979. 169(3): p. 345-7. [Content Brief]
[3]. Champney, W.S. and C.L. Tober, Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol, 2000. 41(2): p. 126-35. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2573 mL | 11.2867 mL | 22.5734 mL | 56.4334 mL |
| 5 mM | 0.4515 mL | 2.2573 mL | 4.5147 mL | 11.2867 mL | |
| 10 mM | 0.2257 mL | 1.1287 mL | 2.2573 mL | 5.6433 mL | |
| 15 mM | 0.1505 mL | 0.7524 mL | 1.5049 mL | 3.7622 mL | |
| 20 mM | 0.1129 mL | 0.5643 mL | 1.1287 mL | 2.8217 mL | |
| 25 mM | 0.0903 mL | 0.4515 mL | 0.9029 mL | 2.2573 mL | |
| 30 mM | 0.0752 mL | 0.3762 mL | 0.7524 mL | 1.8811 mL | |
| 40 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4108 mL | |
| 50 mM | 0.0451 mL | 0.2257 mL | 0.4515 mL | 1.1287 mL | |
| 60 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9406 mL | |
| 80 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7054 mL | |
| 100 mM | 0.0226 mL | 0.1129 mL | 0.2257 mL | 0.5643 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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