Cat. No.: HY-118105

RK-20448

Customer Review

Based on 1 Customer Validation

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC₅₀ values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC₅₀ values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764).

For research use only. We do not sell to patients.

Purity: 99.38%
CAS No.: 479501-40-1
Formula: C₂₉H₃₄N₆O
Molecular Weight:482.62

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

RK-20448 Chemical Structure

CAS No.: 479501-40-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Lck

0.24 μM (IC₅₀)

Blk

0.37 μM (IC₅₀)

Fyn

2.03 μM (IC₅₀)

Tie2

5.85 μM (IC₅₀)

VEGFR2

10.74 μM (IC₅₀)

All Src Isoforms :

All VEGFR Isoforms :

All Tie Isoforms :

Tie1
Tie2

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	25 μM Compound: 13 (trans)	Inhibition of IL-2 production in anti-CD3 stimulated Jurkat cells Inhibition of IL-2 production in anti-CD3 stimulated Jurkat cells	[PMID: 12039590]

Chemical Information

CAS No. 479501-40-1
Appearance Solid
Molecular Weight 482.62
Formula C₂₉H₃₄N₆O
Color White to off-white
SMILES

NC1=C(C2=NC=N1)C(C3=CC=C(C=C3)OC4=CC=CC=C4)=CN2[C@H]5CC[C@H](CC5)N6CCN(CC6)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (51.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0720 mL

10.3601 mL

20.7202 mL

5 mM

0.4144 mL

2.0720 mL

4.1440 mL

10 mM

0.2072 mL

1.0360 mL

2.0720 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saito Y, et al. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013 Apr 17;5(181):181ra52. [Content Brief]

[2]. Almoyad MAA, et al. Hematopoietic cell kinase as a nexus for drug repurposing: implications for cancer and HIV therapy. J Biomol Struct Dyn. 2024 Mar 26:1-11. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0720 mL	10.3601 mL	20.7202 mL	51.8006 mL
	5 mM	0.4144 mL	2.0720 mL	4.1440 mL	10.3601 mL
	10 mM	0.2072 mL	1.0360 mL	2.0720 mL	5.1801 mL
	15 mM	0.1381 mL	0.6907 mL	1.3813 mL	3.4534 mL
	20 mM	0.1036 mL	0.5180 mL	1.0360 mL	2.5900 mL
	25 mM	0.0829 mL	0.4144 mL	0.8288 mL	2.0720 mL
	30 mM	0.0691 mL	0.3453 mL	0.6907 mL	1.7267 mL
	40 mM	0.0518 mL	0.2590 mL	0.5180 mL	1.2950 mL
	50 mM	0.0414 mL	0.2072 mL	0.4144 mL	1.0360 mL

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RK-20448

Anti-Infection Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Cytokine Inhibitors Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

All Src Isoforms

All VEGFR Isoforms

All Tie Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

RK-20448 Related Classifications

HY-118105 Related Classifications