Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck
- Bioorg Med Chem Lett. 2002 Jun 17;12(12):1683-6. doi: 10.1016/s0960-894x(02)00195-6.
Affiliations
- 1. Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA. [email protected]
PMID: 12039590
DOI: 10.1016/s0960-894x(02)00195-6
Abstract
A series of pyrrolo[2,3-d]pyrimidines was synthesized and evaluated as inhibitors of Lck. Lck accommodates a diverse set of substituents at N-7. Altering the substituent at N-7 provided compound 13, an orally available Lck Inhibitor which inhibited TCR mediated IL-2 production after oral dosing.