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Cat. No.: HY-N21783

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Japonipene G

Japonipene G is a bisabolane-type sesquiterpene that exhibits no significant cytotoxicity toward neuronal cells at the tested concentrations, but shows no inhibitory activity against cobalt CoCl₂-induced neuronal cell death. Japonipene G can serve as a negative control or a mechanistic research tool for neuroprotection-related studies.

For research use only. We do not sell to patients.

CAS No.: 1448439-95-9
Formula: C₂₅H₃₅ClO₆
Molecular Weight:466.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Japonipene G Chemical Structure

CAS No.: 1448439-95-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Japonipene G (1.5-15 μM; 2 h pre-treatment) does not exert neuroprotective effects against CoCl₂-induced death in human dopaminergic SH-SY5Y cells at concentrations up to 15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human dopaminergic neuroblastoma SH-SY5Y cells
Concentration:

1.5, 5, 15 μM
Incubation Time:

2 h (pre-treatment before CoCl₂ exposure)
Result:

Showed no neuroprotective activity against CoCl₂-induced neuronal cell death in SH-SY5Y cells.
Exhibited no significant cytotoxicity to SH-SY5Y cells at the tested concentrations.

Chemical Information

CAS No. 1448439-95-9
Molecular Weight 466.99
Formula C₂₅H₃₅ClO₆
SMILES

C/C=C(C)\C(OC(C/C=C(C)/C)C([C@H]1[C@@H](C([C@@](O)([C@@H](C1)Cl)C)=O)OC(/C(C)=C\C)=O)=C)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang S, et al. Isolation, characterization, and neuroprotective activities of sesquiterpenes from Petasites japonicus. Food chemistry. 2013 Dec 01;141(3):2075-82.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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