2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Phosphatase
  4. JCS-1

JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders (Pink: DcpS ligand (HY-102020); Blue: E3 ligase VHL ligand (HY-151227); Black: linker (HY-141230)).

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JCS-1

JCS-1 構造式

CAS 番号 : 3093519-24-2

容量 価格（税別） 在庫状況 数量
5 mg $2250 在庫あり
10 mg $3735 在庫あり
25 mg $7470 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

JCS-1 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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製品説明

JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders (Pink: DcpS ligand (HY-102020); Blue: E3 ligase VHL ligand (HY-151227); Black: linker (HY-141230))[1].

IC50 & Target[1]

VHL

 

体外実験

JCS-1 (0.1-10000 nM, 24 h) degrades DcpS in MOLM-14 cells in a dose-dependent manner with a DC50 of 87 nM[1].
JCS-1 (1 μM) degrades DcpS rapidly and continuously in MOLM-14 cells, with degradation occurring rapidly within 2 h of treatment and maximum degradation occurring between 12 and 24 h[1].
JCS-1 (1 μM, every 3 days for 12 days) inhibits the proliferation and viability of MOLM-14 cells with an IC50 value of 1.1 μM[1].
JCS-1 (1 μM, 6 h) influences the mRNA pool of MOLM-14 cells with significant increase in SNORD99 and DDX24 expression[1].
Degradation by JCS-1 is inhibited by the neddylation inhibitor MLN4924 (HY-70062) and proteasome inhibitor Epoxomicin (HY-13821) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JCS-1 関連抗体
分子量

1174.41

分子式

C62H79N9O12S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](N(CC2=C3C=CC=C2)C3=O)C(C)C)=O)C[C@H](O)C1)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCOCCOCCOCCOCCOCCOC6=CC=CC(CN7CCC(COC8=CC=CC9=NC(N)=NC(N)=C89)CC7)=C6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (85.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8515 mL 4.2575 mL 8.5149 mL
5 mM 0.1703 mL 0.8515 mL 1.7030 mL
10 mM 0.0851 mL 0.4257 mL 0.8515 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8515 mL 4.2575 mL 8.5149 mL 21.2873 mL
5 mM 0.1703 mL 0.8515 mL 1.7030 mL 4.2575 mL
10 mM 0.0851 mL 0.4257 mL 0.8515 mL 2.1287 mL
15 mM 0.0568 mL 0.2838 mL 0.5677 mL 1.4192 mL
20 mM 0.0426 mL 0.2129 mL 0.4257 mL 1.0644 mL
25 mM 0.0341 mL 0.1703 mL 0.3406 mL 0.8515 mL
30 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7096 mL
40 mM 0.0213 mL 0.1064 mL 0.2129 mL 0.5322 mL
50 mM 0.0170 mL 0.0851 mL 0.1703 mL 0.4257 mL
60 mM 0.0142 mL 0.0710 mL 0.1419 mL 0.3548 mL
80 mM 0.0106 mL 0.0532 mL 0.1064 mL 0.2661 mL
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JCS-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JCS-13093519-24-2JCS1JCS 1PROTACsPhosphataseMOLM-14AntiproliferativeAMLProteasomesEpoxEpimer.Inhibitorinhibitorinhibit

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製品名:
JCS-1
製品番号:
HY-164977
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