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Cat. No.: HY-155051

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Antiproliferative agent-25

Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC₅₀: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T_1/2 of only 21.8 and 4.7 min in human and rat liver microsomes.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₁BrN₂O₂
Molecular Weight:401.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antiproliferative agent-25 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

0.11 μM (PRMT5)^[1]

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	14.25 μM Compound: 3s4	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
HepG2	IC₅₀	58.14 μM Compound: 3s4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
L02	IC₅₀	>100 μM Compound: 3s4	Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
MCF7	IC₅₀	28.89 μM Compound: 3s4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]
MDA-MB-231	IC₅₀	21.33 μM Compound: 3s4	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37429083]

Chemical Information

Molecular Weight 401.30
Formula C₂₀H₂₁BrN₂O₂
SMILES

O[C@@H](CN1C=CC2=C1C=C(Br)C=C2)CN(C3)CCC4=C3C=CC(O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chu WH, et al. Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Oct 5;258:115625. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Antiproliferative agent-25

All Histone Methyltransferase Isoforms