Terrein
Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 582-46-7
- Formula: C8H10O3
- Molecular Weight:154.16
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Treatment of Mel-Ab cells with Terrein (10-100 μM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation[1].
Terrein (5-500 μM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners[2].
Terrein (150, 250, 500μM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 μM) were used for subsequent experiments[2].
Terrein (25 and 75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells[2].
Terrein (75 μM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 μM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells[2].
Terrein (10, 30, and 100 μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:5, 25, 50, 75, 100, 150, 250, 500 µM
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Incubation Time:24 and 48 hours
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Result:The IC50s for MCF-7 and MDA-MB-231 cells after 24 h of incubation were 2.34 mM and 700 µM, respectively. After 48 h of incubation, the IC50s are 244.3 µM for MCF-7 and 244.5 µM for MDA-MB-231 cells.
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:25, 75, 150, 250, 500 µM
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Incubation Time:24 hours
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Result:The percentages of apoptotic cells after 25 and 75 µM treatment were 7.52 and 5.82%, respectively for MCF-7 cells (9.94% for the control), and 15.77 and 15.82%, respectively for MDA-MB-231 cells (8.79% for the control).
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:25, 75 µM
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Incubation Time:
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Result:Decreased the mRNA levels of both MMP-2 and MMP-9 in a concentration-dependent manner.
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:75 µM
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Incubation Time:6, 12 and 24 hours
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Result:RhoA and RhoB protein levels were significantly decreased after 6 h of 75 µM treatment in MCF-7 cells.
Phosphorylated (p)-Rac1 was also slightly decreased at 12 h. However, RhoC and Cdc42 levels remained unchanged. RhoB protein levels and Rac1 phosphorylation were also decreased in MDA-MB-231 cells at 12 and 24 h, respectively.
Chemical Information
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CAS No. 582-46-7
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Appearance Solid
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Molecular Weight 154.16
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Formula C8H10O3
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Color White to off-white
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SMILES
O=C1C=C(/C=C/C)[C@H](O)[C@H]1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. S-H Park, et al. Terrein: A New Melanogenesis Inhibitor and Its Mechanism. Cell Mol Life Sci. 2004 Nov;61(22):2878-85. [Content Brief]
[2]. Anongnard Kasorn, et al. Terrein Inhibits Migration of Human Breast Cancer Cells via Inhibition of the Rho and Rac Signaling Pathways. Oncol Rep. 2018 Mar;39(3):1378-1386. [Content Brief]
[3]. Bomin Kim, et al. Terrein Is an Inhibitor of Quorum Sensing and c-di-GMP in Pseudomonas Aeruginosa: A Connection Between Quorum Sensing and c-di-GMP. Sci Rep. 2018 Jun 5;8(1):8617. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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