1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. SNT-207707

SNT-207707 

Cat. No.: HY-11029 Purity: 99.23%
Handling Instructions

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207707 Chemical Structure

SNT-207707 Chemical Structure

CAS No. : 1064662-40-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 363 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 570 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

IC50 & Target

IC50: 8 nM (binding MC-4), 5 nM (function MC-4)[1]

In Vitro

SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1].

In Vivo

Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].

Molecular Weight

550.18

Formula

C₃₂H₄₄ClN₅O

CAS No.

1064662-40-3

SMILES

O=C(C1=CN2C(C=C1)=NC(C3=CC=C(C#N)C=C3)=C2CCCN4CCCC4)N(CCC(C)C)CCC(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (454.40 mM)

Methanol : 250 mg/mL (454.40 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8176 mL 9.0879 mL 18.1759 mL
5 mM 0.3635 mL 1.8176 mL 3.6352 mL
10 mM 0.1818 mL 0.9088 mL 1.8176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]

Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60 mg/kg (n=9 per compound). At 1, 3, and 6 hrs post-dose, 3 mice from each compound group are euthanized with CO2. Blood is collected by cardiac puncture, plasma is isolated immediately and then kept on dry ice until analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product name:
SNT-207707
Cat. No.:
HY-11029
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