2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. SNT-207707

SNT-207707 

Cat. No.: HY-11029 Purity: 99.51%
COA Handling Instructions

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207707 Chemical Structure

SNT-207707 Chemical Structure

CAS No. : 1064662-40-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 363 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 363 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 570 In-stock
50 mg USD 2400 In-stock
100 mg USD 4100 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SNT-207707 Related Antibodies

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  • Biological Activity

  • Protocol

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Description

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

IC50 & Target

IC50: 8 nM (binding MC-4), 5 nM (function MC-4)[1]
In Vitro

SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNT-207707 Related Antibodies
In Vivo

Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

550.18

Appearance

Solid

Formula

C32H44ClN5O
CAS No.
SMILES

O=C(C1=CN2C(C=C1)=NC(C3=CC=C(C#N)C=C3)=C2CCCN4CCCC4)N(CCC(C)C)CCC(C)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (454.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8176 mL 9.0879 mL 18.1759 mL
5 mM 0.3635 mL 1.8176 mL 3.6352 mL
10 mM 0.1818 mL 0.9088 mL 1.8176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
Animal Administration
[1]

Mice[1]

Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60 mg/kg (n=9 per compound). At 1, 3, and 6 hrs post-dose, 3 mice from each compound group are euthanized with CO2. Blood is collected by cardiac puncture, plasma is isolated immediately and then kept on dry ice until analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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SNT-207707 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SNT-2077071064662-40-3SNT207707SNT 207707Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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