1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor

SNT-207707 

Cat. No.: HY-11029
Handling Instructions

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207707 Chemical Structure

SNT-207707 Chemical Structure

CAS No. : 1064662-40-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

IC50 & Target

IC50: 8 nM (binding MC-4), 5 nM (function MC-4)[1]

In Vitro

SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1].

In Vivo

Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].

References
Animal Administration
[1]

Mice[1]

Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60 mg/kg (n=9 per compound). At 1, 3, and 6 hrs post-dose, 3 mice from each compound group are euthanized with CO2. Blood is collected by cardiac puncture, plasma is isolated immediately and then kept on dry ice until analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

550.18

Formula

C₃₂H₄₄ClN₅O

CAS No.

1064662-40-3

SMILES

O=C(C1=CN2C(C=C1)=NC(C3=CC=C(C#N)C=C3)=C2CCCN4CCCC4)N(CCC(C)C)CCC(C)C.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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SNT-207707
Cat. No.:
HY-11029
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SNT-207707

Cat. No.: HY-11029