1064662-40-3
1064662-40-3
Chemical Structure
SNT-207707
- CAS No.: 1064662-40-3
- Formula:C32H44ClN5O
- Molecular Weight:550.18
IUPAC Name: 2-(4-cyanophenyl)-N,N-diisopentyl-3-(3-(pyrrolidin-1-yl)propyl)imidazo[1,2-a]pyridine-6-carboxamide hydrochloride
InChIKey: FBNJDWPWZNPVSC-UHFFFAOYSA-N
SMILES: O=C(C1=CN2C(C=C1)=NC(C3=CC=C(C#N)C=C3)=C2CCCN4CCCC4)N(CCC(C)C)CCC(C)C.Cl
Biological Activity: SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 can cross blood-brain barrier[1][2][3].
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SNT-207707 | 99.54% | SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 can cross blood-brain barrier. | ||||||||||||||||||||
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References
- [1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. [Content Brief]
- [2]. Hernandez CC, et al. Automated Patch Clamp Recordings of GPCR-Gated Ion Channels: Targeting the MC4-R/Kir7.1 Potassium Channel Complex. Methods Mol Biol. 2024;2796:229-248. [Content Brief]
Keywords
