硫酸サルブタモール
Based on 8 publication(s) in Google Scholar
Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 51022-70-9
- 分子式: C13H22NO5S0.5
- 分子量:288.14
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Salbutamol hemisulfate (Standard)
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MedChemExpress（MCE）の使用を引用している文献 Salbutamol hemisulfate
More- Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
- Chin Med J (Engl). 2026 Apr 23. [Abstract]
- J Hazard Mater Lett. 2025 Nov.
- Cell Rep. 2019 Dec 3;29(10):2929-2935.e4. [Abstract]
- Anal Chem. 2025 Jul 15;97(27):14220-14229. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Respir Res. 2022 Dec 28;23(1):380. [Abstract]
- Mol Biol Rep. 2026 Feb 26;53(1):434. [Abstract]
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Bio/Physico-chemical Assay
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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β adrenergic receptor |
Salbutamol (16 μM; 24 h) hemisulfate significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901
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Concentration:16 μM
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Incubation Time:24 h
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Result:Increased β2-AR and ERK levels.Increased β2-AR and ERK levels. Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin). Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
Salbutamol (6 mg/kg; oral administration; 4 weeks) hemisulfate has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin induced diabetic rats[2]
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Dosage:6 mg/kg
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Administration:Oral administration (p.o.); 4 weeks
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Result:Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
化学情報
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CAS 番号 51022-70-9
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性状 Solid
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分子量 288.14
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分子式 C13H22NO5S0.5
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Color White to off-white
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SMILES
OC(C1=CC(CO)=C(O)C=C1)CNC(C)(C)C.O=S(O)(O)=O
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別名
Salbutamol (hemisulfate); Albuterol (hemisulfate); AH-3365 (hemisulfate); アルブテロール硫酸塩
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Nov;11(41):e2402393. PMID: 39229959
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
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Chin Med J (Engl)
Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]2026 Apr 23. PMID: 42036893 -
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Cell Rep
2019 Dec 3;29(10):2929-2935.e4. PMID: 31801060 -
Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Respir Res
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]2022 Dec 28;23(1):380. PMID: 36575527 -
Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
溶剤 & 溶解度
H2O : 100 mg/mL (347.05 mM; Need ultrasonic)
DMSO : 2 mg/mL (6.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (347.05 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (278 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.4705 mL | 17.3527 mL | 34.7053 mL | 86.7634 mL |
| 5 mM | 0.6941 mL | 3.4705 mL | 6.9411 mL | 17.3527 mL | |
| H2O | 10 mM | 0.3471 mL | 1.7353 mL | 3.4705 mL | 8.6763 mL |
| 15 mM | 0.2314 mL | 1.1568 mL | 2.3137 mL | 5.7842 mL | |
| 20 mM | 0.1735 mL | 0.8676 mL | 1.7353 mL | 4.3382 mL | |
| 25 mM | 0.1388 mL | 0.6941 mL | 1.3882 mL | 3.4705 mL | |
| 30 mM | 0.1157 mL | 0.5784 mL | 1.1568 mL | 2.8921 mL | |
| 40 mM | 0.0868 mL | 0.4338 mL | 0.8676 mL | 2.1691 mL | |
| 50 mM | 0.0694 mL | 0.3471 mL | 0.6941 mL | 1.7353 mL | |
| 60 mM | 0.0578 mL | 0.2892 mL | 0.5784 mL | 1.4461 mL | |
| 80 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3471 mL | 0.8676 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Salbutamol hemisulfate 関連分類
HY-B0436 関連分類
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