CI 972 anhydrous
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 115787-68-3
- 分子式: C11H12ClN5OS
- 分子量:297.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ki: 0.83 μM (PNP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | IC50 |
3 μM
Compound: 11c
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Compound was tested for the cytotoxic activity against MOLT-4 lymphoblasts
Compound was tested for the cytotoxic activity against MOLT-4 lymphoblasts
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[PMID: 1578487] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 115787-68-3
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分子量 297.76
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分子式 C11H12ClN5OS
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SMILES
O=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [Content Brief]
[2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CI 972 anhydrous 関連分類
HY-118047 関連分類
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