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TNIK - TRAF2 and NCK interacting kinase Gene

Also Known as MRT54

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23043

About TNIK

Cytogenetic location: 3q26.2-q26.31 Genomic coordinates (GRCh38): 3:171,058,414-171,460,408 (from NCBI)

This gene has 15 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 10.5), small intestine (RPKM 7.1) and 20 other tissues.

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

TNIK Products (9)

mRNA	Protein	Name
NM_001161564.3	NP_001155036.1	TRAF2 and NCK-interacting protein kinase isoform 6
NM_001161565.3	NP_001155037.1	TRAF2 and NCK-interacting protein kinase isoform 7
NM_001161560.3	NP_001155032.1	TRAF2 and NCK-interacting protein kinase isoform 2
NM_001161566.3	NP_001155038.1	TRAF2 and NCK-interacting protein kinase isoform 8
NM_001161561.3	NP_001155033.1	TRAF2 and NCK-interacting protein kinase isoform 3
NM_001161563.3	NP_001155035.1	TRAF2 and NCK-interacting protein kinase isoform 5
NM_015028.4	NP_055843.1	TRAF2 and NCK-interacting protein kinase isoform 1
NR_027767.2
NM_001161562.3	NP_001155034.1	TRAF2 and NCK-interacting protein kinase isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	10521462	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	22797597	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10521462	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15342639	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10521462	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10521462	GOA
involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15342639	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	10521462	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10521462	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10521462	GOA
involved in regulation of dendrite morphogenesis	IDA IDA: Inferred from direct assay	20159449	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22797597	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15342639	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	15342639	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19816403	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNIK Protein Structure

Pkinase

CNH

0
300
600
900
1200
1360 a.a.

Protein Preferred Names	Protein Names
TRAF2 and NCK-interacting protein kinase

TNIK Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TNIK	Q9UKE5	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	22904686
Intra	TNIK	Q9UKE5	TRAF2	Homo sapiens	Q12933	Pull Down	22904686
Intra	TNIK	Q9UKE5	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	22904686
Intra	TNIK	Q9UKE5	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	22904686
Intra	TNIK	Q9UKE5	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	22904686
Intra	TNIK	Q9UKE5	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22904686
Intra	TNIK	Q9UKE5	TRAF6	Homo sapiens	Q9Y4K3	Pull Down	22904686
Intra	TNIK	Q9UKE5	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	22904686
Intra	TNIK	Q9UKE5	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	22904686
Intra	TNIK	Q9UKE5	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	TNIK	Q9UKE5	CTNNB1	Homo sapiens	P35222	Pull Down	19816403
Intra	TNIK	Q9UKE5	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	19816403
Intra	TNIK	Q9UKE5	DISC1	Homo sapiens	Q9NRI5	Pull Down	32707033
Intra	TNIK	Q9UKE5	DISC1	Homo sapiens	Q9NRI5	Anti Tag CoIP	29961565
Intra	TNIK	Q9UKE5	IKBKB	Homo sapiens	O14920	Anti Bait CoIP	22904686
Intra	TNIK	Q9UKE5	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	22904686
Intra	TNIK	Q9UKE5	TCF7L2	Homo sapiens	Q9NQB0	Anti Bait CoIP	19816403
Intra	TNIK	Q9UKE5	TCF7L2	Homo sapiens	Q9NQB0	Pull Down	19816403
Cross	TNIK	Q9UKE5	LMP1	Epstein-Barr virus	P03230	Anti Tag CoIP	22904686
Cross	TNIK	Q9UKE5	LMP1	Epstein-Barr virus	P03230	Anti Bait CoIP	22904686

Cross: Cross-species interaction Intra: Intraspecies interaction

TNIK 抗体

製品番号	製品名	アプリケーション	反応性
HY-P89577	TNIK Antibody (YA8921)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat

Diseases	Alias
Scoliosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Intellectual Developmental Disorder, Autosomal Recessive 54	MRT54 Mental Retardation, Autosomal Recessive 54

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (30)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-160623	Rentosertib		99.96%	Unkown
HY-100830	NCB-0846	Inhibitor	99.61%	Unkown
HY-10371	Pim1/AAK1-IN-1	Inhibitor	98.40%	Unkown
HY-111754	DMX-5804	Inhibitor	99.83%	Unkown
HY-124745	KY-05009		99.88%	Unkown
HY-N3127	Orobol	Inhibitor	99.74%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.79%	Unkown
HY-156816	ON 108600	Inhibitor	98.65%	Unkown
HY-149591	M4K-2009	Inhibitor	99.35%	Unkown
HY-124762	TNIK-IN-1	Inhibitor	99.25%	Unkown
HY-156502	TINK-IN-1	Inhibitor	98.02%	Unkown
HY-162314	TNIK-IN-8	Inhibitor	99.58%	Unkown
HY-122805	PF-794	Inhibitor	99.19%	Unkown
HY-156818	TNIK-IN-7	Inhibitor	99.65%	Unkown
HY-100830A	NCB-0970	Control	98.81%	Unkown
HY-156817	TNIK-IN-6	Inhibitor	98.28%	Unkown
HY-143437	TNIK-IN-5	Inhibitor	99.75%	Unkown
HY-156523	TNIK&MAP4K4-IN-1		99.73%	Unkown
HY-RS14832	Tnik Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14831	TNIK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-143436	TNIK-IN-4	Inhibitor	/	Unkown
HY-145292	TNIK-IN-2	Inhibitor	99.68%	Unkown
HY-163478	TNIK-IN-9	Inhibitor	/	Unkown
HY-179111	HPK1-IN-64	Inhibitor	/	Unkown
HY-181930	TNIK-IN-10		/	Unkown
HY-183059	TNIK-IN-11	Inhibitor	/	Unkown
HY-183950	ALK5-IN-87	Inhibitor	/	Unkown
HY-RS14833	Tnik Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W402208	MAP4K4-IN-7	Inhibitor	/	Unkown
HY-180857	TNIK modulator-1		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	TNIK	VGNC	VGNC:36179
Macaca mulatta	TNIK	VGNC	VGNC:81595
Felis catus	TNIK	VGNC	VGNC:97666
Mus musculus	TNIK	MGD	MGI:1916264
Rattus norvegicus	TNIK	RGD	RGD:1561817
Canis familiaris	TNIK	VGNC	VGNC:47675
Others	TNIK	NCBI