SIGIRR - single Ig and TIR domain containing Gene

Also Known as TIR8; IL-1R8

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 59307

About SIGIRR

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:405,716-417,397 (from NCBI)

This gene has 22 transcripts (splice variants), 176 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues.

Summary

Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGIRR Products (3)

mRNA	Protein	Name
NM_001135053.2	NP_001128525.1	single Ig IL-1-related receptor
NM_001135054.2	NP_001128526.1	single Ig IL-1-related receptor
NM_021805.3	NP_068577.2	single Ig IL-1-related receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	12925853	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of Toll signaling pathway	IMP IMP: Inferred from mutant phenotype	12925853	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in membrane	IMP IMP: Inferred from mutant phenotype	10346978	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGIRR Protein Structure

TIR

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
single Ig IL-1-related receptor	single Ig IL-1R-related molecule

SIGIRR Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SIGIRR	Q6IA17	PALM3	Homo sapiens	A6NDB9	Y2H	21187075
Intra	SIGIRR	Q6IA17	PALM3	Homo sapiens	A6NDB9	Anti Tag CoIP	21187075

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGIRR Proteins

製品番号	製品名	アクセッション番号	純度
HY-P76064	SIGIRR Protein, Human (HEK293, Fc)	Q6IA17-1 (M1-H118)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P76065	SIGIRR Protein, Human (HEK293, His)	Q6IA17-1 (M1-H118)	≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Progressive Myoclonus Epilepsy 8	Emp8 Pme Type 8 Progressive Myoclonic Epilepsy Due To Cers1 Deficiency Progressive Myoclonus Epilepsy Type 8
Loeffler Syndrome	Loeffler'S Pneumonia Loffler'S Syndrome Simple Pulmonary Eosinophilia
Inflammatory Diarrhea
Chemical Colitis
Central Nervous System Tuberculosis	Intracranial Tuberculoma Tuberculoma Of Brain Tuberculosis Of Meninges And Central Nervous System Tuberculous Abscess Of Brain Tuberculoma, Intracranial Tuberculosis, Central Nervous System
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12896	SIGIRR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18099	Sigirr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24573	Sigirr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	SIGIRR	VGNC	VGNC:65140
Canis familiaris	SIGIRR	VGNC	VGNC:46167
Mus musculus	SIGIRR	MGD	MGI:1344402
Rattus norvegicus	SIGIRR	RGD	RGD:1306732
Bos taurus	SIGIRR	VGNC	VGNC:34616
Others	SIGIRR	NCBI