YTHDC2 - YTH domain containing 2 Gene
Also Known as CAHL; hYTHDC2
生物種: Homo sapiens
About YTHDC2
This gene has 7 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 9.0), lymph node (RPKM 7.1) and 25 other tissues.
Summary
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic Cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver Cancer cell line. [provided by RefSeq, Sep 2016]
YTHDC2 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001345975.2 | NP_001332904.1 | 3'-5' RNA helicase YTHDC2 isoform 2 |
| NM_001345976.2 | NP_001332905.1 | 3'-5' RNA helicase YTHDC2 isoform 3 |
| NM_022828.5 | NP_073739.3 | 3'-5' RNA helicase YTHDC2 isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables 3'-5' RNA helicase activity |
IDA
IDA: Inferred from direct assay
|
29033321 | GOA |
| enables ATP-dependent activity, acting on RNA |
IDA
IDA: Inferred from direct assay
|
21559518 | GOA |
| enables N6-methyladenosine-containing RNA reader activity |
IDA
IDA: Inferred from direct assay
|
26318451 | GOA |
| enables RNA polymerase binding |
IPI
IPI: Inferred from physical interaction
|
21559518 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21903422 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in positive regulation by host of viral genome replication |
IMP
IMP: Inferred from mutant phenotype
|
21559518 | GOA |
| involved in response to interleukin-1 |
IDA
IDA: Inferred from direct assay
|
21559518 | GOA |
| involved in response to tumor necrosis factor |
IDA
IDA: Inferred from direct assay
|
21559518 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
21559518 | GOA |
YTHDC2 Protein Structure
R3H: R3H domain (42 - 105)
DEAD: DEAD/DEAH box helicase (198 - 352)
Ank_2: Ankyrin repeats (3 copies) (487 - 565)
Helicase_C: Helicase conserved C-terminal domain (655 - 743)
HA2: Helicase associated domain (HA2) (808 - 901)
OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (939 - 1065)
YTH: YT521-B-like domain (1288 - 1420)
- 0
- 300
- 600
- 900
- 1200
- 1430 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
3'-5' RNA helicase YTHDC2 |
|
YTHDC2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Cross
|
YTHDC2 | Q9H6S0 | Meioc | Mus musculus | A2AG06 | 26742488 | |
|
Intra
|
YTHDC2 | Q9H6S0 | IRF4 | Homo sapiens | Q15306 | 21903422 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Wilms Tumor 1 |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | YTHDC2 | MGD | MGI:2448561 |
| Canis familiaris | YTHDC2 | VGNC | VGNC:48504 |
| Rattus norvegicus | YTHDC2 | RGD | RGD:1563192 |
| Bos taurus | YTHDC2 | VGNC | VGNC:37040 |
| Macaca mulatta | YTHDC2 | VGNC | VGNC:79452 |
| Others | YTHDC2 | NCBI |
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