TMEM175 - transmembrane protein 175 Gene

Also Known as hTMEM175

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84286

About TMEM175

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:932,460-958,656 (from NCBI)

This gene has 22 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in spleen (RPKM 10.8), brain (RPKM 6.7) and 25 other tissues.

Summary

Enables potassium ion leak channel activity. Involved in potassium ion transmembrane transport. Located in endosome and lysosome. Is integral component of endosome membrane and integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM175 Products (7)

mRNA Protein Name
NM_001297423.2 NP_001284352.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297424.2 NP_001284353.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297425.2 NP_001284354.1 endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297426.2 NP_001284355.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297427.2 NP_001284356.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297428.2 NP_001284357.1 endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_032326.4 NP_115702.1 endosomal/lysosomal potassium channel TMEM175 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables arachidonate binding IDA
IDA: Inferred from direct assay
35750034 GOA
enables potassium channel activity IDA
IDA: Inferred from direct assay
28723891 GOA
enables potassium ion leak channel activity IDA
IDA: Inferred from direct assay
26317472 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33505021 GOA
enables proton channel activity IDA
IDA: Inferred from direct assay
35333573 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in lysosomal lumen pH elevation IDA
IDA: Inferred from direct assay
35333573 GOA
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
26317472 GOA
involved in proton transmembrane transport IDA
IDA: Inferred from direct assay
35333573 GOA
involved in regulation of lysosomal lumen pH IDA
IDA: Inferred from direct assay
35750034 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endosome IDA
IDA: Inferred from direct assay
26317472 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
32228865 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
35750034 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
32228865 GOA
located in lysosome IDA
IDA: Inferred from direct assay
26317472 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM175 Protein Structure

DUF1211

DUF1211: Protein of unknown function (DUF1211) (34 - 124)

DUF1211

DUF1211: Protein of unknown function (DUF1211) (259 - 356)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

endosomal/lysosomal potassium channel TMEM175

  • endosomal/lysomomal potassium channel TMEM175

関連疾患

Diseases Alias
Meier-Gorlin Syndrome 3

  • MGORS3

  • Meier-Gorlin Syndrome, Type 3
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Dementia, Lewy Body

  • Lewy Body Dementia

  • Lewy Body Disease

  • Diffuse Lewy Body Disease

  • Dementia With Lewy Bodies

  • DLB

  • Autosomal Dominant Diffuse Lewy Body Disease

  • Cortical Lewy Body Disease

  • Dementia, Lewy Body, Susceptibility To

  • Lewy Body Dementia, Susceptibility To

  • Senile Dementia Of The Lewy Body Type

  • Dementia Of The Lewy Body Type

  • Lbd

  • Diffuse Lewy Body Disease With Gaze Palsy

  • Dysphasic Dementia Hereditary

  • Lewy Body Type Senile Dementia

  • Lewy Body Variant Of Alzheimer Disease

  • Lewy Bodies

  • Lewy Body

  • Dlbd - [Diffuse Lewy Body Disease]

  • Clbd - [Cortical Lewy Body Disease]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-33878 2-PPA Inhibitor 99.98% Unkown
HY-161949 AP-6 Inhibitor 99.84% Unkown
HY-162666 TMEM175 modulator 1 Modulator 98.91% Unkown
HY-RS29457 TMEM175 Monkey Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19555 Tmem175 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181621 Tmem175 modulator 2 Modulator / Unkown
HY-181622 TMEM175 modulator 3 Activator / Unkown
HY-182768 TMEM175 modulator-4 Modulator / Unkown
HY-186253 TMEM175 agonist 1 Agonist / Unkown
HY-186254 TMEM175 agonist 2 Agonist / Unkown
HY-186257 TMEM175 agonist 3 Agonist / Unkown
HY-186258 TMEM175 agonist 4 Agonist / Unkown
HY-186259 TMEM175 agonist 5 Agonist / Unkown
HY-186260 TMEM175 agonist 6 Agonist / Unkown
HY-186261 TMEM175 agonist 7 Agonist / Unkown
HY-RS14683 TMEM175 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182464 DABMA Activator / Unkown
HY-RS26051 Tmem175 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta TMEM175 VGNC VGNC:79736
Bos taurus TMEM175 VGNC VGNC:35999
Felis catus TMEM175 VGNC VGNC:66291
Rattus norvegicus TMEM175 RGD RGD:1309712
Mus musculus TMEM175 MGD MGI:1919642
Canis familiaris TMEM175 VGNC VGNC:47500
Others TMEM175 NCBI