2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. TMEM175 modulator 1

TMEM175 modulator 1 (compound 47) is a TMEM175 modulator.TMEM175 modulator 1 modulates activity of the lysosomal potassium ion channel TMEM175.TMEM175 modulator 1 can be used for the research of parkinson’s disease, dementia, alzheimer’s disease, l-dopa induced dyskinesia.

For research use only. We do not sell to patients.

TMEM175 modulator 1

TMEM175 modulator 1 Chemical Structure

CAS No. : 3038770-25-8

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TMEM175 modulator 1 Related Antibodies

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Description

TMEM175 modulator 1 (compound 47) is a TMEM175 modulator.TMEM175 modulator 1 modulates activity of the lysosomal potassium ion channel TMEM175.TMEM175 modulator 1 can be used for the research of parkinson’s disease, dementia, alzheimer’s disease, l-dopa induced dyskinesia[1].

IC50 & Target

EC50: 60 nM (TMEM175)[1]
In Vitro

TMEM175 modulator 1 (compound 47) (100 μM to 47.7 pM; 5 minutes) acts as a potent positive modulator of human wild-type TMEM175 in HEK293 cells, with an EC50 of 0.060 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TMEM175 modulator 1 Related Antibodies
Molecular Weight

425.40

Formula

C19H22F3N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](C)NC1=NN=C(C2=CC(C)=C(C(F)(F)F)NC2=O)O1)N3CCC4(CC4)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (9.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3507 mL 11.7536 mL 23.5073 mL
5 mM 0.4701 mL 2.3507 mL 4.7015 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3507 mL 11.7536 mL 23.5073 mL 58.7682 mL
5 mM 0.4701 mL 2.3507 mL 4.7015 mL 11.7536 mL
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TMEM175 modulator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMEM175 modulator 13038770-25-8Potassium ChannelKcsAlysosomal potassium ion channeldementiahuman wild-type TMEM175alzheimer’s diseaseparkinson’s diseaseTMEM175HEK293 cellsl-dopa induced dyskinesiaInhibitorinhibitorinhibit

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