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製品番号: HY-163143

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HDAC8-IN-6

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity.

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CAS 番号: 3036403-81-0
分子式: C₁₉H₁₈IN₃O₂
分子量:447.27

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC8-IN-6 構造式

CAS 番号: 3036403-81-0

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価格（税別）

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数量

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity^[1].

IC₅₀ & Target^[1]

HDAC8

5.1 μM (IC₅₀)

HDAC4

23.1 μM (IC₅₀)

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	>200 μM Compound: 3	Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
HL-60	IC₅₀	161 μM Compound: 3	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MOLM-13	IC₅₀	7.08 μM Compound: 3	Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MV4-11	IC₅₀	8.23 μM Compound: 3	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
OCI-AML-3	IC₅₀	27.17 μM Compound: 3	Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
SET-2	IC₅₀	>200 μM Compound: 3	Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
THP-1	IC₅₀	46.5 μM Compound: 3	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]

化学情報

CAS 番号 3036403-81-0
分子量 447.27
分子式 C₁₉H₁₈IN₃O₂
SMILES

C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Keeley AB, et al. Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors. J Med Chem. 2024 Jan 11;67(1):572-585. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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HDAC8-IN-6

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HDAC8-IN-6 関連分類

HY-163143 関連分類