Methyl arachidonate
Based on 1 Customer Validation
Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 2566-89-4
- 分子式: C21H34O2
- 分子量:318.49
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Methyl arachidonate (50 μM; 5 min) is poorly active in activating purified rat brain protein kinase C in a phosphatidylserine- and calcium-free in vitro assay, inducing less than 20% of maximal activation[1].
Methyl arachidonate (1-500 μM; 10 s-3 min) potently activates protein kinase C in intact human platelets in vitro in a concentration- and time-dependent manner, with maximal activation (101.0% of TPA control) at 500 μM for 1 min, and activation is mediated by eicosanoid metabolites, as shown by inhibition by cyclooxygenase and lipoxygenase inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain (mixed sex, weanling age)[2]
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Dosage:42 mg daily; 14 mg daily; 14 mg every 2nd day; 14 mg every 4th day
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Administration:p.o.; 35 days
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Result:Achieved an average total weight increase of 15 g over 35 days (42 mg daily).
Achieved an average total weight increase of 21-28 g over 35 days (14 mg daily), with greater total weight increase than less frequent dosing groups in the 12 days post-treatment.
Achieved an average total weight increase of 14 g over 35 days (14 mg every 2nd day).
Achieved an average total weight increase of 4 g over 35 days (14 mg every 4th day).
Produced partial to complete healing of ankle skin lesions (42 mg daily).
化学情報
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CAS 番号 2566-89-4
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性状 Liquid
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分子量 318.49
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分子式 C21H34O2
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Color White to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC)=O
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別名
Arachidonic acid methyl ester
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
溶剤 & 溶解度
DMSO : 100 mg/mL (313.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
純度とドキュメンテーション
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データシート (265 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Fan XT, et al. Arachidonic acid and related methyl ester mediate protein kinase C activation in intact platelets through the arachidonate metabolism pathways. Biochem Biophys Res Commun. 1990;169(3):933-940. [Content Brief]
[2]. Hume EM, et al. Fat-deficiency disease of rats. The relative curative potencies of methyl linoleate and methyl arachidonate with a note on the action of the methyl esters of fatty acids from cod liver oil. Biochem J. 1940 Jun;34(6):879-83. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1398 mL | 15.6991 mL | 31.3982 mL | 78.4954 mL |
| 5 mM | 0.6280 mL | 3.1398 mL | 6.2796 mL | 15.6991 mL | |
| 10 mM | 0.3140 mL | 1.5699 mL | 3.1398 mL | 7.8495 mL | |
| 15 mM | 0.2093 mL | 1.0466 mL | 2.0932 mL | 5.2330 mL | |
| 20 mM | 0.1570 mL | 0.7850 mL | 1.5699 mL | 3.9248 mL | |
| 25 mM | 0.1256 mL | 0.6280 mL | 1.2559 mL | 3.1398 mL | |
| 30 mM | 0.1047 mL | 0.5233 mL | 1.0466 mL | 2.6165 mL | |
| 40 mM | 0.0785 mL | 0.3925 mL | 0.7850 mL | 1.9624 mL | |
| 50 mM | 0.0628 mL | 0.3140 mL | 0.6280 mL | 1.5699 mL | |
| 60 mM | 0.0523 mL | 0.2617 mL | 0.5233 mL | 1.3083 mL | |
| 80 mM | 0.0392 mL | 0.1962 mL | 0.3925 mL | 0.9812 mL | |
| 100 mM | 0.0314 mL | 0.1570 mL | 0.3140 mL | 0.7850 mL |
Methyl arachidonate 関連分類
HY-W011297 関連分類
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