PS1097
PS1097 is a broad-spectrum antiviral inhibitor with a BVDV RdRp IC50 of 0.64 μM. PS1097 selectively reduces RTN3 protein levels, causes partial RTN3 mRNA reduction, and leaves other endoplasmic reticulum-resident proteins unaffected. PS1097 inhibits replication of Zika virus and multiple viruses that use the endoplasmic reticulum as a replication hub. PS1097 inhibits BVDV RdRp enzymatic activity and exerts activity against Bovine Viral Diarrhea Virus. PS1097 can be used for the research of zika virus infection, usutu virus infection, west nile virus infection, COVID-19, coxsackie b virus 5 infection, chikungunya virus infection, vaccinia virus infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1822320-58-0
- 分子式: C15H8ClN3OS
- 分子量:313.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BHK-21 | CC50 |
100 μM
Compound: 4
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Cytotoxicity against BHK21 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against BHK21 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 26479028] |
体外実験
PS1097 (1.7-100 μM; 48 h) potently inhibits ZIKV Brazil/2016/INMI1 replication in Huh-7 cells with an EC50 of 0.69 μM and a high Selectivity Index of 331.7[1].
PS1097 (100 μM starting serial dilutions; 48 h most assays) exhibits broad-spectrum antiviral activity against multiple RNA and DNA viruses that rely on endoplasmic reticulum remodeling for replication, with EC50 values ranging from 0.1 to 5.51 μM across susceptible virus-cell line pairs, and high Selectivity Indices in most systems[1].
PS1097 (0.6-6 μM; 48 h) dose-dependently inhibits ZIKV NS5 protein synthesis in Huh-7 and Vero E6 cells, with maximal inhibition observed at 6 μM[1].
PS1097 (6 μM; 48 h) potently and selectively downregulates reticulon 3 protein levels in Huh-7 cells, with a partial reduction in corresponding reticulon 3 mRNA levels[1].
PS1097 (1.7-100 μM; 48 h) potently inhibits ZIKVBr replication in Huh-7 cells with an EC50 of 0.69 μM and a high SI of 331.7, indicating strong antiviral activity with low cytotoxicity[2].
PS1097 (0.6-6 μM; 48 h) dose-dependently inhibits ZIKVBr protein synthesis in Huh-7 and Vero E6 cells, leading to reduced viral yield[2].
PS1097 (6 μM; 48 h) potently and selectively downregulates RTN3 protein levels in Huh-7 cells, with a partial reduction in RTN3 mRNA, suggesting a post-transcriptional component to the protein depletion[2].
PS1097 (3-4 days post-viral infection) potently inhibits BVDV-induced cytopathogenicity in MDBK cells with an EC50 of 1.3 μM and shows no significant cytotoxicity up to 100 μM[3].
PS1097 potently inhibits purified BVDV NS5B∆24 polymerase activity with an IC50 of 0.64 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells, Vero E6 cells
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Concentration:0.6 μM (1× EC50), 3 μM (5× EC50), 6 μM (10× EC50)
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Incubation Time:48 h
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Result:Dose-dependently reduced ZIKV NS5 protein levels in both Huh-7 and Vero E6 cells.
Drastically reduced NS5 protein levels at 6 μM compared to untreated infected cells.
Caused corresponding reductions in viral RNA released into supernatants that mirrored intracellular protein levels.
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Cell Line:Huh-7 cells
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Concentration:6 μM
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Incubation Time:48 h
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Result:Caused a significant, selective reduction in RTN3 protein levels (both long and short isoforms) compared to untreated cells, while RTN4, FAM134B, and TMEM41B protein levels remained unchanged.
Reduced RTN3 mRNA levels by approximately 50%, which contributes to but does not fully account for the marked depletion of RTN3 protein.
化学情報
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CAS 番号 1822320-58-0
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分子量 313.76
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分子式 C15H8ClN3OS
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SMILES
O=C1NC2=C(N=C1C3=CC=CS3)C(Cl)=C4N=CC=CC4=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Plicanti E, et al. A Pyrido-Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus. J Med Virol. 2025;97(9):e70605. [Content Brief]
[2]. Briguglio I, et al. Synthesis, cytotoxicity and antiviral evaluation of new series of imidazo[4,5-g]quinoline and pyrido[2,3-g]quinoxalinone derivatives. Eur J Med Chem. 2015;105:63-79. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PS1097 関連分類
HY-186075 関連分類
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