(S)-AMPA
Based on 1 Customer Validation
(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist.
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- 純度: 99%
- CAS 番号: 83643-88-3
- 分子式: C7H10N2O4
- 分子量:186.17
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>1000 μM
Compound: (S)-7
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Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2
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[PMID: 8759641] |
| CHO | EC50 |
220 μM
Compound: (S)-7
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Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6
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[PMID: 8759641] |
| CHO | EC50 |
>1000 μM
Compound: (S)-7
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Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alpha
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[PMID: 8759641] |
| CHO | EC50 |
>3000 μM
Compound: (S)-7
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Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a
Agonist activity of the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4a
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[PMID: 8759641] |
Superfusion of (S)-AMPA (1 μM) significantly attenuates CGRP release in a CB1-dependent manner[3].
24-h exposure to (S)-AMPA (0.01-1000 μM) induces concentration-dependent neuronal cell death (EC50 of 3 μM) with cellular changes including neurite blebbing, chromatin condensation, and DNA fragmentation, indicative of apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 83643-88-3
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性状 Solid
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分子量 186.17
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分子式 C7H10N2O4
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Color Off-white to light yellow
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SMILES
O=C1C(C[C@H](N)C(O)=O)=C(C)ON1
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別名
L-AMPA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 40 mg/mL (214.86 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. J A Larm, et al. (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314(1-2):249-54. [Content Brief]
[2]. B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA. Neurochem Int. 1994 Jun;24(6):507-15. [Content Brief]
[3]. J W Brooks, et al. (S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. Neurosci Lett. 2004 Nov 30;372(1-2):85-8. [Content Brief]
[4]. J A Larm, et al. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem. 1997 Aug;69(2):617-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.3714 mL | 26.8572 mL | 53.7143 mL | 134.2859 mL |
| 5 mM | 1.0743 mL | 5.3714 mL | 10.7429 mL | 26.8572 mL | |
| 10 mM | 0.5371 mL | 2.6857 mL | 5.3714 mL | 13.4286 mL | |
| 15 mM | 0.3581 mL | 1.7905 mL | 3.5810 mL | 8.9524 mL | |
| 20 mM | 0.2686 mL | 1.3429 mL | 2.6857 mL | 6.7143 mL | |
| 25 mM | 0.2149 mL | 1.0743 mL | 2.1486 mL | 5.3714 mL | |
| 30 mM | 0.1790 mL | 0.8952 mL | 1.7905 mL | 4.4762 mL | |
| 40 mM | 0.1343 mL | 0.6714 mL | 1.3429 mL | 3.3571 mL | |
| 50 mM | 0.1074 mL | 0.5371 mL | 1.0743 mL | 2.6857 mL | |
| 60 mM | 0.0895 mL | 0.4476 mL | 0.8952 mL | 2.2381 mL | |
| 80 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6786 mL | |
| 100 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3429 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S)-AMPA 関連分類
HY-100815A 関連分類
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