SMYD3-IN-2
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C26H21BrN2O4
- 分子量:505.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
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SMYD3 0.81 μM μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| BGC-823 | IC50 |
0.75 μM
Compound: 7r
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Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation by MTT assay
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[PMID: 36527933] |
SMYD3-IN-2 (compound 7r) (1.0 μM) exhibits potent inhibitory capacity against SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively[1].
SMYD3-IN-2 (1.0 μM; 24 h) can suppress Akt methylation and activation by SMYD3[1].
SMYD3-IN-2 (0-48 h) suppresses the proliferation of BGC823 stomach adenocarcinoma cells by inducing autophagic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BGC823 cells
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Concentration:1.0 μM
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Incubation Time:24 h
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Result:Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft Balb/c nude mice models[1]
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Dosage:15 and 30 mg/kg
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Administration:Intraperitoneally administration
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Result:Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner.
Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.
化学情報
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分子量 505.36
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分子式 C26H21BrN2O4
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SMILES
[H][C@]12CN(C([C@]1(O[C@@]3([C@@H]2C4=CC=C(C=C4)Br)C(NC5=CC=CC=C53)=O)O)=O)CC6=CC=CC=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SMYD3-IN-2 関連分類
HY-152228 関連分類
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