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製品番号: HY-N21841

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Stypodiol

Stypodiol is an orally active sesquiterpenoid that can be isolated from Stypopodium flabelliforme. Stypodiol exhibits anticancer, gastric mucosal protective, and weak antibacterial activities. Stypodiol is used in research related to colon adenocarcinoma, neuroblastoma, basophilic leukemia, macrophage carcinoma, and gastric mucosal injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 71106-25-7
分子式: C₂₇H₄₀O₄
分子量:428.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Stypodiol 構造式

CAS 番号: 71106-25-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
AGS	IC₅₀	153 μM	Cytotoxicity against human epithelial gastric AGS cells assessed as reduction in cell viability incubated for 48 h by MTT assay. Cytotoxicity against human epithelial gastric AGS cells assessed as reduction in cell viability incubated for 48 h by MTT assay.	25830679
Fibroblast	IC₅₀	215 μM	Cytotoxicity against human fibroblasts assessed as reduction in cell viability incubated for 48 h by MTT assay. Cytotoxicity against human fibroblasts assessed as reduction in cell viability incubated for 48 h by MTT assay.	25830679

体外実験

Stypodiol (12.5-50 μM; 48 h) selectively and concentration-dependently inhibits the proliferation of the RAW.267, SH-SY5Y, Caco-2, and RBL-2H3 cancer cell lines, exhibits very low activity against the non-cancerous V79 cell line, and achieves near-complete inhibition of SH-SY5Y cells at a concentration of 50 μM^[1].
Stypodiol (up to 500 μM; 48 h) inhibits the viability of human gastric epithelial AGS cells and fibroblasts, with IC₅₀ values of 153 μM and 215 μM, respectively^[2].
Stypodiol (24 h) exhibits weak antibacterial activity, with an MIC of 206 μg/mL against E. faecalis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

RAW.267, SH-SY5Y, Caco-2, RBL-2H3, V79
Concentration:

12.5, 25, 50 µM
Incubation Time:

48 h
Result:

Showed a concentration-dependent inhibitory effect on the proliferation of all tested cancer cell lines, but exhibited less toxicity to the non-cancer cell line V79, demonstrating selectivity.

体内実験

Stypodiol (40 mg/kg; p.o.; single administration; 50 min pre-treatment prior to 1 h of HCl/EtOH induction) exerts a gastroprotective effect against gastric mucosal injury in a mouse model of HCl/EtOH-induced gastric mucosal damage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino mice (30 g)^[2]
Dosage:

40 mg/kg
Administration:

p.o.; single dose; 50 min pre-treatment prior to 1 h of HCl/EtOH induction
Result:

Reduced the appearance of gastric mucosal lesions.
Decreased the gastric lesion index by 69%.

化学情報

CAS 番号 71106-25-7
分子量 428.60
分子式 C₂₇H₄₀O₄
SMILES

C[C@]12[C@@]3([C@H](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)C)CC5=C(O)C(O)=CC(C)=C5O3
Structure Classification
- Terpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pereira DM, et al. Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines. Marine drugs. 2011;9(5):852-862.

[2]. Areche C, et al. Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model. Marine drugs. 2015 Mar 30;13(4):1726-38.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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